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BCL2 / Bcl-2
B-cell CLL/lymphoma 2
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| Gene Name: | B-cell CLL/lymphoma 2 |
| Family/Subfamily: | Apoptosis |
| Synonyms: | BCL2, Apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2, PPP1R50 |
| Target Sequences: | NM_000633 NP_000624.2 P10415 |
Publications (10)
1
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Cancer cell. 2007 12:171-85. (IP)
[PubMed:17692808]
2
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule. Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q. The Journal of biological chemistry. 2012 287:1054-65.
[PubMed:22065578]
[PMC:PMC3256916]
Related Antibodies: LS-C98842.
3
The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Hamed SS, Al-Yhya NA, El-Khadragy MF, Al-Olayan EM, Alajmi RA, Hassan ZK, Hassan SB, Abdel Moneim AE. Frontiers in physiology. 2016 August;7:325. [Full Text Article]
[PubMed:27547187]
[PMC:PMC4974471]
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BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa46-95) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
BCL2 / Bcl-2 Rabbit anti-Human Monoclonal (Concentrated) (E17) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$1,169
BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa75-110) Antibody
Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
BCL2 / Bcl-2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (BL-2) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$380
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Magnetic beads) (BL-2) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (124) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
50 µg/$460
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Azide-free, BSA-free) (124) Antibody
Dog, Pig, Human, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
BCL2 / Bcl-2 Rabbit anti-Mouse Polyclonal (aa67-86) Antibody
Mouse, Rat
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Recombinant Monoclonal (rBCL2/782) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
Cancer Pathology
Cancer
BCL2 / Bcl-2 Mouse anti-Human Recombinant Monoclonal (rBCL2/796) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
100 µg/$525
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (Bcl-2/100) Antibody
Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
Unconjugated
0.05 mg/$460
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (100/D5) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (100/D5) Antibody
Dog, Pig, Human, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
50 µg/$460
BCL2 / Bcl-2 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$316; 100 µl/$386
BCL2 / Bcl-2 Rabbit anti-Human Polyclonal (aa85-134) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
BCL2 / Bcl-2 Mouse anti-Human Polyclonal (N-term) (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
BCL2 / Bcl-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1 mg/$485
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (Biotin) (1E1-D10-F4) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$343
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (11C5) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
BCL2 / Bcl-2 Mouse anti-Human Monoclonal (aa41-54) (8C8) Antibody
Dog, Pig, Human, Monkey, Chimpanzee
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
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