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Infectious Disease
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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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BAFF / TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were recently identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.
| Gene Name: | tumor necrosis factor (ligand) superfamily, member 13b |
| Family/Subfamily: | TNF , not assigned-TNF |
| Synonyms: | TNFSF13B, B-cell-activating factor, BAFF, ApoL related ligand TALL-1, B-lymphocyte stimulator, CD257, BLYS, Delta4 BAFF, Delta BAFF, TALL-1, TALL1, ZTNF4, THANK, B lymphocyte stimulator, CD257 antigen, TNFSF20 |
| Target Sequences: | NM_006573 NP_006564.1 Q9Y275 |
Publications (3)
1
SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis. Eri Itotagawa, Yoshihiko Tomofuji, Yasuhiro Kato, Hachiro Konaka, Kohei Tsujimoto, JeongHoon Park, Daiki Nagira, Takehiro Hirayama, Tatsunori Jo, Toru Hirano, Takayoshi Morita, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Yukinori Okada, Hyota Takamatsu, Atsushi Kumanogoh. Rheumatology (Oxford, England). 2023 May;62:1988-1997. [Full Text Article]
[PubMed:36094336]
[PMC:PMC10152287]
Related Antibodies: LS-B2081.
2
Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity. Ueda-Hayakawa I, Tanimura H, Osawa M, Iwasaka H, Ohe S, Yamazaki F, Mizuno K, Okamoto H. Rheumatology (Oxford, England). 2013 Sep;52:1658-66. [Full Text Article]
[PubMed:23685362]
Related Antibodies: LS-B2375.
3
B Lymphocyte Stimulator (BLyS) is expressed in human adipocytes in vivo and is related to obesity but not to insulin resistance. M[Character fc]ller N, Schulte DM, Hillebrand S, T[Character fc]rk K, Hampe J, Schafmayer C, Brosch M, von Sch[Character f6]nfels W, Ahrens M, Zeuner R, Schr[Character f6]der JO, Bl[Character fc]her M, Gutschow C, Freitag-Wolf S, Stelmach-Mardas M, Saggau C, Schreiber S, Laudes M. PloS one. 2014 9:e94282. [Full Text Article]
[PubMed:24728308]
[PMC:PMC3984119]
Related Antibodies: LS-B2081.
☰ Filters
Products
Proteins
(30)
Type
Over-Expression Lysate
(2)
Recombinant
(28)
Target
BAFF / TNFSF13B
(30)
Format
Animal-free
(1)
Publications
No
(30)
Tag
6His, N-terminus
(1)
DDK (Flag)
(2)
Fc
(2)
Fc, N-terminus
(2)
GST
(1)
GST, N-terminus
(1)
His
(4)
His, N-Terminal
(1)
His-DDK (Flag), N-terminus
(1)
His-SUMO
(1)
Human IgG1 Fc
(1)
Mouse IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(25)
Mouse
(4)
Source
293T Cells
(1)
CHO Cells
(4)
E. coli
(12)
HEK 293 Cells
(5)
Human
(2)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(2)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(18)
Biologically Active
Biologically active
(7)
Animal-free
Animal-free
(1)
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$411; 500 µg/$985; 20 µg/$276
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.0 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
5 µg/$282; 20 µg/$370
E. coli
None
Biologically active
17.2 kDa
5 µg/$282; 100 µg/$1,466; 500 µg/$3,025
E. coli
His
20.6 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
His
27.7 kDa
10 µg/$265; 50 µg/$347; 100 µg/$545; 200 µg/$682; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866
Wheat Germ Extract
GST
57.09 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
17 kDa
100 µg/$1,159; 1 mg/$5,413
E. coli
None
17.2 kDa
20 µg/$360; 100 µg/$728
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
43.7 kDa
100 µg/$767; 1 mg/$4,063
293T Cells
Myc-DDK (Flag)
31 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
31 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
31 kDa
20 µg/$1,107
Human
Mouse IgG1 Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.9 kDa
10 µg/$290; 50 µg/$446
Human
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.3 kDa
10 µg/$331; 50 µg/$593
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18 kDa
20 µg/$291; 1 mg/$2,269
Mammalian Cells
Fc, N-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
CHO Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
The 173 amino acid recombinant protein has a predicted molecular mass of approximately 19.2 kD. The protein migrates at approximately 20 kD in DTT-reducing and non-reducing conditions by SDS-PAGE. The predicted N-terminal amino acid is His.
10 µg/$306; 25 µg/$383; 100 µg/$869
CHO Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
The 204 amino acid recombinant protein has a predicted molecular mass of approximately 22.8 kD. The DTT-reduced and non-reduced protein migrate at approximately 20-25 and 50-55 kD by SDS-PAGE respectively. The N-terminal contains a 9His-2(SGGG)-IEGR-tag.
10 µg/$355
Mammalian Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
43.3 kDa
10 µg/$288; 50 µg/$436
HEK 293 Cells
His-DDK (Flag), N-terminus
19 kDa
20 µg/$1,107
E. coli
His, N-Terminal
Less than 0.1 EU/µg protein (determined by LAL method).
19.2 kDa
100 µg/$677
E. coli
His-SUMO
39.7 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CHO Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
50kDa or 100kDa or 300kDa
10 µg/$344
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