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Vector Laboratories, Inc.
6737 Mowry Ave
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BACE1 / BACE

beta-site APP-cleaving enzyme 1

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Gene Name: beta-site APP-cleaving enzyme 1
Family/Subfamily: Protease , Aspartic A1
Synonyms: BACE1, APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, Aspartylprotease 2, Beta-secretase, Beta-site APP-cleaving enzyme, BACE, HSPC104, KIAA1149, B-Secretase, Beta-secretase 1, Memapsin-2
Target Sequences: NM_012104 NP_036236.1 P56817

Publications (1)

1
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. BMC biology. 2016 14:25. (WB; Human) [Full Text Article] [PubMed:27036734] [PMC:PMC4818459]

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Antibodies (83)
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BACE1 / BACE Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BACE1 / BACE Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
BACE1 / BACE Antibody - Anti-BACE1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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BACE1 / BACE Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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BACE1 / BACE Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, IP, Neut, WB
Unconjugated
100 µg/$941
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Microplate
Human
1.024 - 250 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
BACE1 / BACE Antibody - Anti-BACE1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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BACE1 / BACE Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.25 - 16 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
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BACE1 / BACE Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$930
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BACE1 / BACE Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
BACE1 / BACE Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE Antibody. The picture on the right is blocked with the synthesized peptide.
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BACE1 / BACE Rabbit anti-Human Polyclonal (aa452-501) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
BACE1 / BACE Antibody - Anti-BACE1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
BACE1 / BACE Rabbit anti-Human Polyclonal (aa72-121) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
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BACE1 / BACE Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$860
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
BACE1 / BACE Antibody - Immunohistochemistry of BACE in mouse brain tissue with BACE antibody at 2.5 µg/ml.
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
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BACE1 / BACE Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
20 µl/$469; 100 µl/$702
BACE1 / BACE Antibody - BACE1 antibody Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BACE1 / BACE Rabbit anti-Mouse Polyclonal (aa251-300) Antibody
Mouse
WB
Unconjugated
100 µl/$424
BACE1 / BACE Antibody - Western blot of BACE1 / BACE antibody.
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BACE1 / BACE Rabbit anti-Human Polyclonal (aa170-428) Antibody
Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
BACE1 / BACE Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland tissue using BACE1 Antibody at dilution of 1:100
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
BACE1 / BACE ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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BACE1 / BACE Rabbit anti-Human Polyclonal (440-520 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BACE1 / BACE Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using BACE antibody.
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BACE1 / BACE Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
Viewing 1-25 of 128 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).