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AXIN2 / Axin 2

axin 2

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Gene Name: axin 2
Synonyms: AXIN2, AXIL, Axin-2, Axis inhibition protein 2, Axin 2, Axin-like protein, Conductin
Target Sequences: NM_004655 NP_004646.3 Q9Y2T1

Publications (1)

1
Maternal Huluwa dictates the embryonic body axis through ß-catenin in vertebrates. Yan L, Chen J, Zhu X, Sun J, Wu X, Shen W, Zhang W, Tao Q, Meng A. Science (New York, N.Y.). 2018 November;362: [Full Text Article] [PubMed:30467143] Related Antibodies: LS-C345085.

☰ Filters
Antibodies (54)
ELISA Kits (17)
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Over-Expression Lysate (2)
Primary (54)
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AXIN2 / Axin 2 (77)
Human (59)
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mouse (1)
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monoclonal mc (2)
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AXIN2 / Axin 2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.05 mg/$460
AXIN2 / Axin 2 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
AXIN2 / Axin 2 Antibody - Western blot of AXIN2 Antibody with human Jurkat Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
AXIN2 / Axin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
AXIN2 / Axin 2 Antibody - Immunofluorescent analysis of Axin-2 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
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AXIN2 / Axin 2 Rabbit anti-Human Monoclonal (Pro556) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$688
AXIN2 / Axin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AXIN2 / Axin 2 Antibody - AXIN2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
AXIN2 / Axin 2 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AXIN2 / Axin 2 Protein - Recombinant Axis Inhibition Protein 2 By SDS-PAGE
Select
E. coli
His
32.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
AXIN2 / Axin 2 Antibody - Immunohistochemistry of paraffin-embedded rat kidney using AXIN2 antibody at dilution of 1:200 (x400 lens).
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
AXIN2 / Axin 2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa350-631) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (aa816-843) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
AXIN2 / Axin 2 Antibody - Western blot of AXIN2 Antibody with human 293T Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Rabbit, Guinea pig, Bovine, Rat, Pig, Human
WB
HRP Conjugated
100 µl/$469
AXIN2 / Axin 2 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AXIN2 / Axin 2 Antibody - Immunohistochemistry image of paraffin-embedded human brain tissue at a dilution of 1:100
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
AXIN2 / Axin 2 Antibody - 1:100 staining rat heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
AXIN2 / Axin 2 Antibody - Detection limit for recombinant GST tagged AXIN2 is 0.3 ng/ml as a capture antibody.
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AXIN2 / Axin 2 Mouse anti-Human Monoclonal (3B6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
AXIN2 / Axin 2 Antibody - Immunohistochemistry analysis using Rabbit Anti-Axin-2 Polyclonal Antibody. Tissue: Lung Cancer. Species: Human. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-Axin-2 Polyclonal Antibody  at 1:50 for 30 min at RT. Counterstain: Hematoxylin. Magnification: 10X.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$442
AXIN2 / Axin 2 Antibody - Immunohistochemistry analysis using Rabbit Anti-Axin-2 Polyclonal Antibody. Tissue: Lung Cancer. Species: Human. Fixation: Formalin Fixed Paraffin-Embedded. Primary Antibody: Rabbit Anti-Axin-2 Polyclonal Antibody  at 1:50 for 30 min at RT. Counterstain: Hematoxylin. Magnification: 10X.
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AXIN2 / Axin 2 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, WB
Unconjugated
100 µg/$442
Viewing 1-25 of 77 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).