AXIN2, also known as conductin, is a member of the WNT signaling pathway and maintains the degradation and phosphorylation of B-Catenin (CTNNB1) alongside APC, AXIN1, CK1, and CSK3B in basal colorectal cells. It plays an important role in cell cycle control, as it maintains beta-catenin stability and negatively regulates WNT signaling. Beta-catenin deregulation plays a large role in the formation and progression of a number of cancers. Mutations in AXIN2 have been associated in particular with colorectal cancer of the microsatellite-unstable (MSI) phenotype. Loss of function of AXIN2 in these cancers contributes to aberrant activation of WNT signaling and tumorigenesis. Germline mutations in this gene are also associated with a predisposition for colorectal carcinoma. In immunohistochemistry, AXIN2 has cytoplasmic and nuclear positivity in all tissues throughout the body.