ATR

ataxia telangiectasia and Rad3 related

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

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Products

Antibodies (43)

Proteins (3)

ELISA Kits (2)

Type

Competitive EIA (1)

Primary (43)

Recombinant (3)

Sandwich (1)

Target

ATR (48)

Reactivity

Human (44)

Mouse (8)

Rat (2)

Dog (1)

Fish (1)

Horse (1)

Monkey (2)

Rabbit (1)

Xenopus (1)

Application

IHC (17)

IHC-P (5)

WB (24)

ELISA (18)

ICC (1)

IF (2)

IP (2)

Peptide-ELISA (3)

Host

rabbit (40)

mouse (2)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (33)

IgG1 (1)

IgG1,k (1)

Clonality

monoclonal mc (2)

polyclonal pc (41)

Clone

1E9 (1)

4D7 (1)

Format

96-Well Strip Plate (2)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (28)

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Epitope

aa2353-2644 (8)

C-Terminus (6)

pSer428 (4)

370-450 aa (2)

Ab-428 (1)

Ser428 (1)

aa1675-1725 (1)

aa2405-2644 (1)

aa394-443 (1)

aa400-450 (1)

Publications

No (48)

Sample Type

Plasma (2)

Serum (2)

Tag

GST, N-terminus (1)

His, N-Terminal (1)

His-T7, N-terminus (1)

Species

Human (3)

Source

E. coli (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ ATR Antibody (clone 1E9) LS-B4288

(4.0) Rating

Antibody:

ATR Mouse anti-Human Monoclonal (1E9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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ATR Antibody (aa394-443) LS-C118345

Antibody:

ATR Rabbit anti-Human Polyclonal (aa394-443) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ATR Antibody LS-C60116

Antibody:

ATR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Xenopus, Fish, Rat, Mouse, Dog, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$567

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ATR Antibody LS-C677251

Antibody:

ATR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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ATR Antibody (phospho-Ser428) LS-C806721

Antibody:

ATR Rabbit anti-Human Polyclonal (pSer428) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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ATR Antibody (phospho-Ser428) LS-C198655

Antibody:

ATR Rabbit anti-Human Polyclonal (pSer428) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

ATR Antibody LS-C815233

Antibody:

ATR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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Human ATR Protein (Recombinant His, N-Terminal) (aa2353-2644) - LS-G26069

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

37.4 kDa

Price:

10 µg/$281; 50 µg/$442; 200 µg/$882; 1 mg/$1,989; 5 mg/$3,081; 2 mg/$2,176

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ATR Antibody (370-450 aa) LS-C382213

Antibody:

ATR Rabbit anti-Human Polyclonal (370-450 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ATR Antibody (C-Terminus) LS-C326891

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

Select

ATR Antibody (C-Terminus, Biotin) LS-C218671

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

ATR Antibody (C-Terminus, FITC) LS-C218672

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

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ATR Antibody (C-Terminus, APC) LS-C218670

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

Select

ATR Antibody (C-Terminus, PE) LS-C218675

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

Select

ATR Antibody (C-Terminus, Azide-free, HRP) LS-C218673

Antibody:

ATR Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

ATR Antibody (370-450 aa) LS-C381660

Antibody:

ATR Rabbit anti-Human Polyclonal (370-450 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

ATR Antibody (phospho-Ser428) LS-C750562

Antibody:

ATR Rabbit anti-Human Polyclonal (pSer428) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

Select

ATR Antibody (Ab-428) LS-C825522

Antibody:

ATR Rabbit anti-Human Polyclonal (Ab-428) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

ATR Antibody LS-C832628

Antibody:

ATR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

ATR Antibody (phospho-Ser428) LS-C825521

Antibody:

ATR Rabbit anti-Human Polyclonal (pSer428) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

ATR Antibody LS-C659679

Antibody:

ATR Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

ATR Antibody (aa1675-1725) LS-C287066

Antibody:

ATR Rabbit anti-Human Polyclonal (aa1675-1725) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ATR Antibody (aa400-450) LS-C287064

Antibody:

ATR Rabbit anti-Human Polyclonal (aa400-450) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ATR Antibody (Ser428) LS-C92170

Antibody:

ATR Rabbit anti-Human Polyclonal (Ser428) Antibody

Reactivity:

Rabbit, Horse, Human, Monkey

Applications:

IHC

Format:

Unconjugated

Price:

100 µg/$523

Select

ATR Antibody (clone 4D7) LS-C179836

Antibody:

ATR Mouse anti-Human Monoclonal (4D7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$400

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