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AQP4 / Aquaporin 4

aquaporin 4

AQP4, also known as Mercurial-insensitive water channel (MIWC), is the fourth member of the aquaporin water channel family. This osmoreceptor regulates body water balance and mediates water flow within the central nervous system. It appears to play some specific role in the functioning of skeletal muscles, retina, and auditory system. Contrary to other aquaporin family members, AQP4 is not inhibited by mercurial compounds. The expression of AQP4 is reduced in the skeletal muscles of Duchenne muscular dystrophy syndrome patients. In addition, a dysfunction of the AQP4 may contribute to the development of brain edema; some results indicate that interference with the subcellular localization of this protein may have a therapeutic potential for delaying the onset of this pathological condition.

Gene Name: aquaporin 4
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP4, Aquaporin type4, Aquaporin 4, Aquaporin-4, HMIWC2, MIWC, WCH4, AQP-4
Target Sequences: NM_001650 NP_001641.1 P55087

Publications (5)

1
Aquaporin pathways and mucin secretion of Bowman's glands might protect the olfactory mucosa. Solbu TT, Holen T. Chemical senses. 2012 37:35-46. (IHC; Rat) [Full Text Article] [PubMed:21745799] Related Antibodies: LS-C3805.
2
Resveratrol ameliorates oxidative stress and inhibits aquaporin 4 expression following rat cerebral ischemia-reperfusion injury. Li W, Tan C, Liu Y, Liu X, Wang X, Gui Y, Qin L, Deng F, Yu Z, Hu C, Chen L. Molecular medicine reports. 2015 November;12:7756-62. (Human) [Full Text Article] [PubMed:26458999] Related Antibodies: LS-C3805.
3
Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Daniel G Couch, Hollie Cook, Catherine Ortori, Dave Barrett, Jonathan N Lund, Saoirse E O'Sullivan. Inflammatory bowel diseases. 2019 May;25:1006-1018. [Full Text Article] [PubMed:31054246]
4
Effects of caffeic acid phenethyl ester in reducing cerebral edema in rat subjects experiencing brain injury: An in vivo study. Rizha Anshori Nasution, Andi Asadul Islam, Mochammad Hatta, Prihantono, Warsinggih, Dany H Ludong, Ismail, Harakati Wangi, Muh Nassrum Massi, Khairul Ihsan Nasution. Annals of medicine and surgery (2012). 2020 September;57:328-333. [Full Text Article] [PubMed:32874565] [PMC:PMC7452142]
5
Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic-ischemic brain injury. Jennifer K Lee, Dapeng Liu, Dengrong Jiang, Ewa Kulikowicz, Aylin Tekes, Peiying Liu, Qin Qin, Raymond C Koehler, Manisha Aggarwal, Jiangyang Zhang, Lee J Martin. The Journal of comparative neurology. 2021 July;529:2750-2770. [Full Text Article] [PubMed:33543493] [PMC:PMC8113130] Related Antibodies: LS-B11637, LS-C413484.
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ELISA Kits (29)
Competitive EIA (2)
Custom (3)
Development Kit (3)
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AQP4 / Aquaporin 4 (29)
Human (8)
Mouse (7)
Rat (7)
Chicken (1)
Guinea pig (1)
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12 x 8-Well Microstrips (3)
96-Well Microplate (4)
96-Well Strip Plate (19)
Antibody Pair and Standard (3)
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Yes (2)
Cell Culture Supernatants (4)
Cell Lysates (4)
Plasma (17)
Serum (17)
Tissue Homogenates (9)
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AQP4 / Aquaporin 4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$764
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AQP4 / Aquaporin 4 ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
AQP4 / Aquaporin 4 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
AQP4 / Aquaporin 4 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Mouse
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
AQP4 / Aquaporin 4 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
AQP4 / Aquaporin 4 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,207; 1000 Wells/$1,787
AQP4 / Aquaporin 4 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
AQP4 / Aquaporin 4 ELISA Kit
Select
Competitive EIA
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP4 / Aquaporin 4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).