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Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
Gene Name: | apolipoprotein C-III |
Synonyms: | APOC3, Apo-CIII, Apolipoprotein C3, APOCIII, HALP2, ApoC-III, Apolipoprotein C-III |
Target Sequences: | NM_000040 NP_000031.1 P02656 |
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