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Infectious Disease
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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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APOA1 / Apolipoprotein A 1
apolipoprotein A-I
APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease.
| Gene Name: | apolipoprotein A-I |
| Synonyms: | APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI |
| Target Sequences: | NM_000039 NP_000030.1 P02647 |
Publications (6)
1
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43.
[PubMed:16418537]
2
A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-1. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4826-32.
[PubMed:16982924]
3
Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B. Human molecular genetics. 2013 22:1289-99. (ICC, IHC; Mouse)
[PubMed:23255163]
☰ Filters
Products
Proteins
(33)
Type
Native
(2)
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(27)
Target
APOA1 / Apolipoprotein A 1
(33)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(3)
Publications
No
(33)
Tag
6His, C-terminus
(3)
6His, N-terminus
(3)
8His, N-terminus
(1)
Fc
(1)
Fc, C-terminus
(1)
GST
(1)
His
(5)
His, N-Terminal
(1)
His,C-terminus
(4)
His,N-terminus
(1)
His-GST
(1)
His-T7
(1)
Human IgG1 Fc, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Dog
(1)
Goat
(1)
Human
(22)
Mouse
(5)
Pig
(1)
Rabbit
(1)
Source
293T Cells
(1)
Dog
(1)
E. coli
(15)
HEK 293 Cells
(10)
Human
(1)
Human Cells
(2)
Mammalian Cells
(1)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(8)
Low Endotoxin Level
Low endotoxin level
(14)
Biologically Active
Biologically active
(1)
Yeast
6His, N-terminus
29.5 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
E. coli
None
Less than 0.1 ng/µg of protein (less than 1EU/µg).
28.2 kDa
20 µg/$268; 100 µg/$349
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
His, N-Terminal
18.5 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
28.96kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
E. coli
His,N-terminus
SDS-PAGE
The recombinant human APOA1 consists of 263 amino acids and predicts a molecular mass of 30.7 kDa. It migrates as an approximately 27-31 kDa band in SDS-PAGE under reducing conditions.
100 µg/$480; 1 mg/$2,339
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human APOA1/Fc is a disulfide-linked homodimeric protein.The reduced monomer consists of 481 amino acids migrates as approximately 55 kDa band in SDS-PAGE under reducing conditions as predicted.
100 µg/$480; 1 mg/$2,339
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse ApoA1 comprises 257 amino acids and has a predicted molecular mass of 30.2 kDa. The apparent molecular mass of the protein is approximately 27-31 kDa in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$480
HEK 293 Cells
Myc-DDK (Flag)
28.9 kDa
20 µg/$1,107
E. coli
His
30.7 kDa
100 µg/$926; 1 mg/$3,499
HEK 293 Cells
Myc-DDK (Flag)
30.78 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
30.78 kDa
20 µg/$150
E. coli
115 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
12.76 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
HEK 293 Cells
Human IgG1 Fc, N-terminus
Less than 0.06 EU/µg protein (determined by LAL method).
100 µg/$519
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
55 kDa
100 µg/$926; 1 mg/$4,191
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2 kDa
10 µg/$248; 50 µg/$288
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2 kDa
100 µg/$926
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
29.0 kDa
10 µg/$288; 50 µg/$436
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30 kDa
10 µg/$288; 50 µg/$436
Dog
None
29.0 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,441
Wheat Germ Extract
GST
55.11 kDa
10 µg/$479; 25 µg/$670
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