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APLNR/ Apelin Receptor / APJ

apelin receptor

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Gene Name: apelin receptor
Family/Subfamily: GPCR , Apelin
Synonyms: APLNR, AGTRL1, Angiotensin receptor-like 1, Angiotensin II receptor-like 1, Apelin receptor, APJ, APJ (apelin) receptor, APJR, G protein-coupled receptor APJ, HG11 orphan receptor, HG11, APJ receptor, G-protein coupled receptor APJ
Target Sequences: NM_005161 NP_005152.1 P35414

Publications (2)

1
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Ashley EA, Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, Deng A, Eichhorn J, Mahajan R, Agrawal R, Greve J, Robbins R, Patterson AJ, Bernstein D and Quertermous T. Cardiovascular research. 2005 65:73-82. (IHC-P; Mouse, Human) [PubMed:15621035] [PMC:PMC2517138]
2
Apelin retards the progression of diabetic nephropathy. Day RT, Cavaglieri RC, Feliers D. American journal of physiology. Renal physiology. 2013 Mar;304:F788-800. [Full Text Article] [PubMed:23303408] [PMC:PMC3602700] Related Antibodies: LS-A64.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
APLNR/ Apelin Receptor / APJ (4)
No (4)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
APLNR/ Apelin Receptor / APJ Protein - Purified recombinant protein APLNR was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
42.5 kDa
20 µg/$1,107
APLNR/ Apelin Receptor / APJ Protein - 12.5% SDS-PAGE of human AGTRL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
67.54 kDa
2 µg/$439
APLNR/ Apelin Receptor / APJ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
42.5 kDa
20 µg/$150
APLNR/ Apelin Receptor / APJ Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
42.5 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).