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ANXA1 / Annexin A1

annexin A1

Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35000 to 40000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kD, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.

Gene Name: annexin A1
Synonyms: ANXA1, Annexin A1, Annexin I, Annexin-1, ANX1, Calpactin II, Chromobindin-9, Lipocortin I, Annexin I (lipocortin I), Calpactin-2, LPC1
Target Sequences: NM_000700 NP_000691.1 P04083

Publications (5)

1
Exposure to chemical cocktails before or after conception – The effect of timing on ovarian development. Bellingham M, Amezaga MR, Mandon-Pepin B, Speers CJ, Kyle CE, Evans NP, Sharpe RM, Cotinot C, Rhind SM, Fowler PA. Molecular and cellular endocrinology. 2013 Aug;376:156-72. (WB; Sheep) [Full Text Article] [PubMed:23791816] Related Antibodies: LS-B3028.
2
Annexin A1 modulates macula densa function by inhibiting cyclooxygenase 2. Seidel S, Neymeyer H, Kahl T, R[Character f6]schel T, Mutig K, Flower R, Schnermann J, Bachmann S, Paliege A. American journal of physiology. Renal physiology. 2012 Sep;303:F845-54. [Full Text Article] [PubMed:22791338] Related Antibodies: LS-C20640.
3
Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers. Gao Y, Chen Y, Xu D, Wang J, Yu G. BMC cancer. 2014 14:520. (IHC-P; Human) [Full Text Article] [PubMed:25038797] [PMC:PMC4223377]
4
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines. Bernadette Jeremiasse, Csaba Matta, Christopher R Fellows, David J Boocock, Julia R Smith, Susan Liddell, Floris Lafeber, Willem E van Spil, Ali Mobasheri. BMC molecular and cell biology. 2020 June;21:47. [Full Text Article] [PubMed:32586320] [PMC:PMC7318434]
5
Specialized pro-resolution mediators in the bladder: Receptor expression and recovery of bladder function from cystitis. Francis M Hughes Jr, Armand Allkanjari, Michael R Odom, Huixia Jin, J Todd Purves. Experimental biology and medicine (Maywood, N.J.). 2022 April;247:700-711. [Full Text Article] [PubMed:35044873] [PMC:PMC9039492]
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Proteins (24)
Over-Expression Lysate (3)
Recombinant (20)
ANXA1 / Annexin A1 (24)
No (24)
6His, N-terminus (2)
8His, N-terminus (1)
GST (2)
GST, N-terminus (1)
His (3)
His, N-Terminal (1)
His, N-terminus (1)
His-S (6)
Myc-DDK (Flag) (3)
Guinea pig (1)
Human (13)
Mouse (4)
Pig (1)
Rabbit (2)
Rat (2)
293T Cells (1)
E. coli (16)
HEK 293 Cells (3)
Wheat Germ Extract (3)
Yeast (1)
Purified (4)
Low endotoxin level (2)
ANXA1 / Annexin A1 Protein
Select
E. coli
6His, N-terminus
41 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 500 µg/$949
ANXA1 / Annexin A1 Protein - Recombinant Annexin A1 By SDS-PAGE
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E. coli
His-S
44.2 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
Select
E. coli
His-S
44.3 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
ANXA1 / Annexin A1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
ANXA1 / Annexin A1 Protein - Recombinant Annexin A1 By SDS-PAGE
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E. coli
His, N-terminus
44.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
ANXA1 / Annexin A1 Protein - Recombinant Annexin A1 By SDS-PAGE
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E. coli
His-S
43.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
38.58kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
ANXA1 / Annexin A1 Protein - Purified recombinant protein ANXA1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
38.5 kDa
20 µg/$1,107
ANXA1 / Annexin A1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.5 kDa
100 µg/$494
Select
Yeast
6His, N-terminus
40.6 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
ANXA1 / Annexin A1 Protein - Recombinant Annexin A1 By SDS-PAGE
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E. coli
His-S
18.7 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
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E. coli
His-S
20.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
E. coli
His-S
20.3 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
ANXA1 / Annexin A1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
38.5 kDa
20 µg/$150
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
38.6 kDa
20 µg/$388; 100 µg/$862
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E. coli
None
38.7 kDa
2 µg/$456; 10 µg/$651; 100 µg/$2,312
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E. coli
His, N-Terminal
44.3kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$3,201
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E. coli
His
42.7 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
ANXA1 / Annexin A1 Protein - 12.5% SDS-PAGE of human ANXA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
63.8 kDa
10 µg/$479; 25 µg/$670
ANXA1 / Annexin A1 Protein - 12.5% SDS-PAGE of human ANXA1 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.1 kDa
10 µg/$479; 25 µg/$670
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HEK 293 Cells
8His, N-terminus
41 kDa
100 µg/$298
Select
E. coli
His
42.4 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ANXA1 / Annexin A1 Protein
Select
E. coli
None
38.7 kDa
20 µg/$411; 100 µg/$985; 4 µg/$276
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).