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ALPL / Alkaline Phosphatase
alkaline phosphatase, liver/bone/kidney
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
| Gene Name: | alkaline phosphatase, liver/bone/kidney |
| Synonyms: | ALPL, Alkaline phosphomonoesterase, AP-TNAP, Alkaline phosphatase liver, APTNAP, Glycerophosphatase, Tissue-nonspecific ALP, TNAP, HOPS, Liver alkaline phosphatase, TNSALP |
| Target Sequences: | NM_000478 NP_000469.3 P05186 |
Publications (1)
1
Collagen-Hydroxyapatite Scaffolds Induce Human Adipose Derived Stem Cells Osteogenic Differentiation In Vitro. Calabrese G, Giuffrida R, Fabbi C, Figallo E, Lo Furno D, Gulino R, Colarossi C, Fullone F, Giuffrida R, Parenti R, Memeo L, Forte S. PloS one. 2016 11:e0151181. (WB, ELISA, IHC-Fr; Bovine, Human)
[Full Text Article]
[PubMed:26982592]
[PMC:PMC4794180]
Related Antibodies: LS-C98218.
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ALPL / Alkaline Phosphatase
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ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (aa18-502) (2F4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Bovine, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$575
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (FITC) Antibody
Bovine, Human
ELISA, WB
FITC Conjugated
100 µl/$951
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (TRA-2-49/6E) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, IF, IP
Unconjugated
100 µg/$880
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (HRP) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
HRP Conjugated
100 µl/$1,094
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (Biotin) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
Biotin Conjugated
100 µl/$1,094
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (FITC) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
FITC Conjugated
100 µl/$1,094
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (APC) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
APC Conjugated
100 µl/$1,094
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (PE) Antibody
Rabbit, Pig, Cat, Human, Monkey
Flo, ICC, IF, IP
PE Conjugated
100 µl/$1,094
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa3-32) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
Competitive EIA
96-Well Strip Plate
Human
3.12 - 200 U/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa28-501) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (4H1) Antibody
Human
ELISA, RNAi, WB
Unconjugated
100 µg/$423
ALPL / Alkaline Phosphatase Rat anti-Human Monoclonal (aa18-502) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$896
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa3-32) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
200 µg/$677
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
100 µl/$951
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal (aa1-359) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ALPL / Alkaline Phosphatase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$331
ALPL / Alkaline Phosphatase Mouse anti-Human Monoclonal (2F4) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µg/$503
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