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Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Gene Name: | arachidonate 15-lipoxygenase, type B |
Family/Subfamily: | Lipoxygenase , Not assigned-Other |
Synonyms: | ALOX15B, 15S-lipoxygenase, 15-lipoxygenase 2, 15-LOX-2, 15-LOX-B, Arachidonate 15-lipoxygenase B, Arachidonate 15-lipoxygenase 2 |
Target Sequences: | NM_001141 NP_001132.2 O15296 |
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