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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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ALDP / ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
ALDP / ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.
| Gene Name: | ATP-binding cassette, sub-family D (ALD), member 1 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCD/ALD |
| Synonyms: | ABCD1, ABC42, Adrenoleukodystrophy protein, ALD, Aldgh, Adrenoleukodystrophy, ALDP, X-ALD |
| Target Sequences: | NM_000033 NP_000024.2 P33897 |
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