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ADGRV1 / GPR98
G protein-coupled receptor 98
Very Large G Protein-Coupled Receptor-1 (VLGR1) is an Orphan-A GPCR with an unknown ligand. VLGR1 consists of three expressed isoforms. VLGR1 has a large ectodomain containing multiple CALX-beta repeats that resemble regulatory domains of sodium-calcium exchanger proteins. VLGR1b, which is the only form expressed in mouse, is apparently the largest known cell-surface protein with an ectodomain containing 35 CALX- repeats and a pentraxin homology domain. The MASS1 gene, which is a fragment of the very large G-protein-coupled receptor VLGR1, is mutated in the Frings mouse model of audiogenic epilepsy.
| Gene Name: | G protein-coupled receptor 98 |
| Family/Subfamily: | GPCR , Orphan-A |
| Synonyms: | ADGRV1, FEB4, KIAA0686, G-protein coupled receptor 98, MASS1, VLGR1b, Usher syndrome type-2C protein, USH2B, USH2C, G protein-coupled receptor 98, GPR98, KIAA1943, VLGR1 |
| Target Sequences: | AF435925 AAL30811.1 Q8WXG9 |
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