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ADGRE5 / CD97 is a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
Gene Name: | CD97 molecule |
Family/Subfamily: | GPCR , CD55 |
Synonyms: | ADGRE5, CD97, CD97 molecule, Leukocyte antigen CD97, TM7LN1, CD97 antigen |
Target Sequences: | NM_078481 NP_510966.1 P48960 |
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