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ACTG1 / Gamma Actin

actin, gamma 1

Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.

Gene Name: actin, gamma 1
Synonyms: ACTG1, ACTG, Actin, gamma 1, BRWS2, Cytoskeletal gamma-actin, DFNA20, Actin, cytoplasmic 2, Gamma-actin, DFNA26
Target Sequences: NM_001614 NP_001605.1 P63261

Publications (14)

1
Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Watters JW, Kraja A, Meucci MA, Province MA, McLeod HL. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:11809-14. [PubMed:15282376] [PMC:PMC511056]
2
Localization and role of NPC1L1 in cholesterol absorption in human intestine. San AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Mnard D, Beaulieu JF, Levy E. Journal of lipid research. 2006 47:2112-20. [PubMed:16829661]
3
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Boutz PL, Chawla G, Stoilov P, Black DL. Genes & development. 2007 21:71-84. [PubMed:17210790] [PMC:PMC1759902]
4
Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus. Kolokoltsov AA, Deniger D, Fleming EH, Roberts NJ, Karpilow JM, Davey RA. Journal of virology. 2007 81:7786-800. [PubMed:17494077] [PMC:PMC1933373]
5
Effects of dietary decosahexaenoic acid (DHA) on eNOS in human coronary artery endothelial cells. Stebbins CL, Stice JP, Hart CM, Mbai FN, Knowlton AA. Journal of cardiovascular pharmacology and therapeutics. 2008 13:261-8. [PubMed:18682551]
6
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling. Goffart S, Cooper HM, Tyynismaa H, Wanrooij S, Suomalainen A, Spelbrink JN. Human molecular genetics. 2009 18:328-40. [PubMed:18971204] [PMC:PMC2638771]
7
Preferential killing of breast tumor initiating cells by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine/tesmilifene. Deng T, Liu JC, Pritchard KI, Eisen A, Zacksenhaus E. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:119-30. [PubMed:19118039]
8
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Blood. 2009 113:5568-74. [PubMed:19336759] [PMC:PMC2689054]
9
Human Dna2 is a nuclear and mitochondrial DNA maintenance protein. Duxin JP, Dao B, Martinsson P, Rajala N, Guittat L, Campbell JL, Spelbrink JN, Stewart SA. Molecular and cellular biology. 2009 29:4274-82. [PubMed:19487465] [PMC:PMC2715806]
10
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL. Virology. 2011 420:73-81. [PubMed:21943826] [PMC:PMC3204369]
11
The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus. Cmarik JL, Troxler JA, Hanson CA, Zhang X, Ruscetti SK. Viruses. 2011 3:2442-61. [PubMed:22355448] [PMC:PMC3280514]
12
Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ, Stewart SA. The Journal of biological chemistry. 2012 287:21980-91. (WB; Human) [PubMed:22570476] [PMC:PMC3381158]
13
Krppel-like factor 10 upregulates the expression of cyclooxygenase 1 and further modulates angiogenesis in endothelial cell and platelet aggregation in gene-deficient mice. Yang DH, Hsu CF, Lin CY, Guo JY, Yu WC, Chang VH. The international journal of biochemistry & cell biology. 2013 45:419-28. (WB; Mouse, Human) [PubMed:23178857]
14
Polarization of membrane associated proteins in the choroid plexus epithelium from normal and slc4a10 knockout mice. Christensen IB, Gyldenholm T, Damkier HH, Praetorius J. Frontiers in physiology. 2013 4:344. (IHC; Mouse) [Full Text Article] [PubMed:24348423] [PMC:PMC3842056] Related Antibodies: LS-C34852.
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ACTG1 / Gamma Actin (51)
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ACTG1 / Gamma Actin Antibody - Anti-ACTG1 / Gamma Actin antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa188-215) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
ACTG1 / Gamma Actin Antibody - Anti-ACTG1 / Gamma-Actin antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ACTG1 / Gamma Actin Mouse anti-Human Monoclonal (2A3) Antibody
Chicken, Rabbit, Mouse, Rat, Pig, Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
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ACTG1 / Gamma Actin Sheep anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ICC, IHC, WB
Unconjugated
100 µl/$842
ACTG1 / Gamma Actin Antibody - Anti-ACTG1 / Gamma-Actin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ACTG1 / Gamma Actin Antibody - Anti-ACTG1 / Gamma Actin antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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ACTG1 / Gamma Actin Mouse anti-Human Monoclonal (N-Terminus) (2A3) Antibody
Mouse, Mammal, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
ACTG1 / Gamma Actin Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using ACTG1 Antibody at dilution of 1:100
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
ACTG1 / Gamma Actin Protein
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E. coli
His
43.3 kDa
10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
ACTG1 / Gamma Actin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.63 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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E. coli
His, N-Terminal
43.3kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
ACTG1 / Gamma Actin ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ACTG1 / Gamma Actin Antibody - Detection of Human Actin by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-Actin used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, WB
Unconjugated
10 µl/$295; 100 µl/$514
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ACTG1 / Gamma Actin Rabbit Recombinant Monoclonal Antibody
ICC, IHC, WB
Unconjugated
10 µl/$299; 100 µl/$548
ACTG1 / Gamma Actin Antibody - Immunohistochemical analysis of Gamma-actin-1 staining in human muscle formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated, Preservative Free
50 µg/$343
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
ACTG1 / Gamma Actin Antibody
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µl/$332
ACTG1 / Gamma Actin Antibody - Western blot of recombinant ACTG1 / Gamma Actin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
ACTG1 / Gamma Actin Antibody - Western blot of recombinant ACTG1 / Gamma Actin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
ACTG1 / Gamma Actin Antibody - Western blot of recombinant ACTG1 / Gamma Actin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$313; 200 µl/$357; 500 µl/$503; 1 ml/$576; 2 ml/$788; 5 ml/$1,279
ACTG1 / Gamma Actin Antibody - Western blot of recombinant ACTG1 / Gamma Actin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$341; 200 µl/$397; 500 µl/$583; 1 ml/$715; 2 ml/$953; 5 ml/$1,628
ACTG1 / Gamma Actin Antibody - Western blot of recombinant ACTG1 / Gamma Actin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
ACTG1 / Gamma Actin Antibody - Detection limit for recombinant GST tagged ACTG1 is 1 ng/ml as a capture antibody.
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ACTG1 / Gamma Actin Mouse anti-Human Monoclonal (1G6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
ACTG1 / Gamma Actin Antibody - Western blot of ACTG1 / Gamma Actin antibody.
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ACTG1 / Gamma Actin Rabbit anti-Human Polyclonal (aa1-375) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543
Viewing 1-25 of 51 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).