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Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
Gene Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
Synonyms: | ABCB5, ABCB5alpha, ABCB5 P-gp, ABCB5beta, ATP-binding cassette protein, EST422562, P-glycoprotein ABCB5 |
Target Sequences: | NM_178559 NP_848654.3 Q2M3G0 |
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