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ABCB1 / MDR1 / P Glycoprotein

ATP-binding cassette, sub-family B (MDR/TAP), member 1

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1
Target Sequences: NM_000927 NP_000918.2 P08183

Publications (6)

1
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human) [Full Text Article] [PubMed:22734885] [PMC:PMC3457850] Related Antibodies: LS-A9403.
2
miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Liu S, Tetzlaff MT, Wang T, Yang R, Xie L, Zhang G, Krepler C, Xiao M, Beqiri M, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Xu W, Wei Z, Herlyn M, Yao Y, Zhang L, Wang Y, Zhang L, Xu X. Pigment cell & melanoma research. 2015 28:431-41. (WB; Human) [Full Text Article] [PubMed:25903073] [PMC:PMC4597606] Related Antibodies: LS-B1448.
3
Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome. Hiroshi Kikuchi, Nako Maishi, Dorcas A Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, Masumi Sato, Masahiro Morimoto, Ryo Takeda, Keita Ishizuka, Ryuji Matsumoto, Tomoshige Akino, Kunihiko Tsuchiya, Takashige Abe, Takahiro Osawa, Naoto Miyajima, Satoru Maruyama, Toru Harabayashi, Manabu Azuma, Katsushige Yamashiro, Kaname Ameda, Akira Kashiwagi, Yoshihiro Matsuno, Yasuhiro Hida, Nobuo Shinohara, Kyoko Hida. Cancer research. 2020 July;80:2996-3008. [Full Text Article] [PubMed:32536602] Related Antibodies: LS-B1448.
4
Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells. Sharad Sharma, Zhe Li, David Bussing, Dhaval K Shah. Drug metabolism and disposition: the biological fate of chemicals. 2020 May;48:368-377. [Full Text Article] [PubMed:32086295] [PMC:PMC7153564]
5
Prognostic significance of miR-23b in combination with P-gp, MRP and LRP/MVP expression in non-small cell lung cancer. M Janikova, V Zizkova, J Skarda, G Kharaishvili, L Radova, Z Kolar. Neoplasma. 2016 June;63:576-87. [Full Text Article] [PubMed:27268921] Related Antibodies: LS-C58240.
6
miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Liu S, Tetzlaff MT, Cui R, Xu X. The American journal of pathology. 2012 Nov;181:1823-35. [Full Text Article] [PubMed:22982443] [PMC:PMC3483804] Related Antibodies: LS-B1448.
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ABCB1 / MDR1 / P Glycoprotein (13)
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ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
50 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Ascites, Plasma, Serum, Tissue Homogenates
1 Plate/$1,002
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$715
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
50 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
ABCB1 / MDR1 / P Glycoprotein ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).