AAK1

AP2 associated kinase 1

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.

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Products

Antibodies (34)

Type

Primary (34)

Target

AAK1 (34)

Reactivity

Human (26)

Mouse (19)

Rat (10)

Bat (1)

Chicken (3)

Dog (3)

Gibbon (3)

Horse (4)

Monkey (5)

Rabbit (3)

Application

IHC (11)

IHC-P (3)

WB (31)

ELISA (21)

ICC (1)

IF (3)

IP (2)

Peptide-ELISA (2)

Host

rabbit (26)

mouse (7)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (18)

IgG2a,k (6)

IgG2b (1)

Clonality

monoclonal mc (7)

polyclonal pc (27)

Clone

12K1 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (18)

Epitope

aa279-306 (7)

aa593-642 (4)

240-320 aa, Internal (1)

aa186-216 (1)

aa271-320 (1)

aa310-360 (1)

aa315-415 (1)

aa350-410 (1)

aa677-691 (1)

aa704-822 (1)

aa790-819 (1)

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Publications

No (34)

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IHC-plus™ AAK1 Antibody LS-B3843

(4.0) Rating

Antibody:

AAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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AAK1 Antibody (aa704-822, clone 12K1) LS-C182750

Antibody:

AAK1 Mouse anti-Human Monoclonal (aa704-822) (12K1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$896

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AAK1 Antibody LS-C500941

Antibody:

AAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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AAK1 Antibody (240-320 aa, Internal) LS-C381842

Antibody:

AAK1 Rabbit anti-Human Polyclonal (240-320 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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IHC-plus™ AAK1 Antibody LS-B3833

(4.0) Rating

Antibody:

AAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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AAK1 Antibody (aa279-306) LS-C319233

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

AAK1 Antibody (aa279-306, Biotin) LS-C232290

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

AAK1 Antibody (aa279-306, FITC) LS-C232291

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

AAK1 Antibody (aa279-306, Azide-free, HRP) LS-C249352

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

AAK1 Antibody (aa279-306, APC) LS-C232288

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

AAK1 Antibody (aa279-306, PE) LS-C232294

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

AAK1 Antibody (aa279-306) LS-C164282

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa279-306) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

AAK1 Antibody (aa315-415) LS-C306011

Antibody:

AAK1 Mouse anti-Human Monoclonal (aa315-415) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

AAK1 Antibody (HRP) LS-C540661

Antibody:

AAK1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

Select

AAK1 Antibody (Biotin) LS-C520530

Antibody:

AAK1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

Select

AAK1 Antibody (FITC) LS-C530575

Antibody:

AAK1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

AAK1 Antibody (APC) LS-C512315

Antibody:

AAK1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

Select

AAK1 Antibody (PE) LS-C648773

Antibody:

AAK1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

Select

AAK1 Antibody LS-C822982

Antibody:

AAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

AAK1 Antibody LS-C831719

Antibody:

AAK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

AAK1 Antibody (aa310-360) LS-C288897

Antibody:

AAK1 Rabbit anti-Human Polyclonal (aa310-360) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

AAK1 Antibody (aa350-410) LS-C288900

Antibody:

AAK1 Rabbit anti-Human Polyclonal (aa350-410) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

AAK1 Antibody (aa271-320) LS-C119088

Antibody:

AAK1 Rabbit anti-Human Polyclonal (aa271-320) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

AAK1 Antibody (aa677-691) LS-C112877

Antibody:

AAK1 Goat anti-Human Polyclonal (aa677-691) Antibody

Reactivity:

Horse, Bat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

AAK1 Antibody (aa593-642) LS-C145232

Antibody:

AAK1 Rabbit anti-Mouse Polyclonal (aa593-642) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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