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| Catalog Number | Size | Price |
|---|---|---|
| LS-C500941-50 | 50 µg | $294 |
| LS-C500941-100 | 100 µg | $360 |
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Polyclonal Rabbit anti‑Human AAK1 Antibody (IHC, IF, WB) LS‑C500941
Polyclonal Rabbit anti‑Human AAK1 Antibody (IHC, IF, WB) LS‑C500941
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
AAK1 antibody LS-C500941 is an unconjugated rabbit polyclonal antibody to AAK1 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Target
Human AAK1
Synonyms
AAK1 | Adaptor-associated kinase 1 | AP2 associated kinase 1 | KIAA1048
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
Specificity
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Applications
- IHC
- Immunofluorescence
- Western blot
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
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Requested From: United States
Date Requested: 12/25/2024
Date Requested: 12/25/2024
