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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
DPP4 is a cell surface glycoprotein receptor that functions in immune regulation, apoptosis, signal transduction, glucose metabolism and regulation of insulin secretion. It can inactivate GLP-1, PACAP and GIP, which each stimulate insulin secretion in the pancreas and reduce glucose levels. It acts as a positive regulator of T-cell coactivation and induces T-cell proliferation and NF-kappa-B activation, and it is involved in lymphocyte-epithelial cell adhesion. In disease, DPP4 contributes to fibrosis in the liver, kidney and other organs, and it is also deregulated in a number of cancers. Furthermore, it is a target of therapies in diabetes. In immunohistochemistry, DPP4 has luminal membranous positivity in the parathyroid, small intestine, kidney, endometrium, placenta and prostate.
References: Journal of Gastroenterology. 2014. 49 (3): 481–91, PMID: 23475323; Front Immunol. 2015; 6: 386, PMID: 26284071