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DPP4 / CD26
dipeptidyl-peptidase 4
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
| Gene Name: | dipeptidyl-peptidase 4 |
| Family/Subfamily: | Protease , Serine S9B |
| Synonyms: | DPP4, ADCP-2, ADABP, Dipeptidyl peptidase IV, Dipeptidyl-peptidase 4, DPPIV, ADCP2, T-cell activation antigen CD26, CD26, CD26 antigen, Dipeptidyl peptidase 4, Dipeptidylpeptidase 4, DPP IV, TP103 |
| Target Sequences: | NM_001935 NP_001926.2 P27487 |
Publications (2)
1
Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay. Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON. Proceedings of the National Academy of Sciences of the United States of America. 2016 113:4482-7. (WB; Rat)
[Full Text Article]
[PubMed:27044116]
[PMC:PMC4843433]
2
Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines. Amatya VJ, Takeshima Y, Kushitani K, Yamada T, Morimoto C, Inai K. Oncology reports. 2011 26:1369-75. (IHC-P; Human)
[Full Text Article]
[PubMed:21894438]
Related Antibodies: LS-A8060.
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(215)
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DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
DPP4 / CD26 Mouse anti-Human Monoclonal (11D7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
DPP4 / CD26 Rabbit anti-Human Polyclonal (aa663-712) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DPP4 / CD26 Rabbit anti-Human Polyclonal (aa663-712) (Biotin) Antibody
Rabbit, Mouse, Rat, Horse, Orangutan, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
Sandwich
96-Well Microplate
Rat
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Monkey
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
DPP4 / CD26 Mouse anti-Human Monoclonal (M-A261) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
25 µg/$281; 0.1 mg/$385; 0.2 mg/$471
DPP4 / CD26 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DPP4 / CD26 Goat anti-Rat Polyclonal (Internal Region) Antibody
Rat
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Fast Shipping
DPP4 / CD26 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
DPP4 / CD26 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IP
Unconjugated
100 µg/$558
DPP4 / CD26 Mouse anti-Rat Monoclonal (Biotin) (OX-61) Antibody
Rat
Flo, IHC, IHC-Fr, IP, WB
Biotin Conjugated
100 µg/$355; 500 µg/$541
DPP4 / CD26 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
DPP4 / CD26 Rabbit anti-Human Polyclonal (aa484-728) Antibody
Pig, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
DPP4 / CD26 Mouse anti-Human Monoclonal (DPP4/910) Antibody
Rat, Human
Flo, IF, IHC, IHC-Fr
Unconjugated
20 µg/$371; 100 µg/$574
DPP4 / CD26 Mouse anti-Rat Monoclonal (PE) (OX-61) Antibody
Rat
Flo
PE Conjugated
50 µg/$357; 200 µg/$660
DPP4 / CD26 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$581
Sandwich
96-Well Microplate
Mouse
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
DPP4 / CD26 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
Flo, IHC, IHC-Fr, IP
Biotin Conjugated
100 Tests/$643
DPP4 / CD26 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
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