TAAR2 (Trace amine-associated receptor 2, GPR58) is a G protein-coupled receptor that binds 3-iodo-thyronamine (T1AM) and is involved in regulating trace amine and dopaminergenic signaling. TAAR1 is required for biogenic amine-induced white blood cell activation in granulocytes. Separately, mutations in TAAR2 have been associated with schizophrenia, and this receptor may play an important role in dopaminergic signaling and neurotransmission in various neuropsychiatric diseases. In immunohistochemistry, TAAR2 has membranous positivity in the cerebellum, on olfactory sensory neurons in the olfactory epithelium, and on leukocytes. References: Biomedicine & Pharmacotherapy. 83: 439–449, PMID: 27424325; Journal of Leukocyte Biology. 93 (3): 387–94, PMID: 23315425; Expert Opin Ther Targets. 2018 Jun;22(6):513-526, PMID: 29798691