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| Catalog Number | Size | Price |
|---|---|---|
| LS-A326-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human TAAR2 / GPR58 Antibody (Cytoplasmic Domain, IHC) LS‑A326
PathPlus™ Polyclonal Rabbit anti‑Human TAAR2 / GPR58 Antibody (Cytoplasmic Domain, IHC) LS‑A326
Antibody:
TAAR2 / GPR58 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
TAAR2 / GPR58 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TAAR2 (Trace amine-associated receptor 2, GPR58) is a G protein-coupled receptor that binds 3-iodo-thyronamine (T1AM) and is involved in regulating trace amine and dopaminergenic signaling. TAAR1 is required for biogenic amine-induced white blood cell activation in granulocytes. Separately, mutations in TAAR2 have been associated with schizophrenia, and this receptor may play an important role in dopaminergic signaling and neurotransmission in various neuropsychiatric diseases. In immunohistochemistry, TAAR2 has membranous positivity in the cerebellum, on olfactory sensory neurons in the olfactory epithelium, and on leukocytes.
References: Biomedicine & Pharmacotherapy. 83: 439–449, PMID: 27424325; Journal of Leukocyte Biology. 93 (3): 387–94, PMID: 23315425; Expert Opin Ther Targets. 2018 Jun;22(6):513-526, PMID: 29798691
Target
Human TAAR2 / GPR58
Synonyms
TAAR2 | G-protein coupled receptor 58 | GPR58 | TaR-2 | Trace amine receptor 2 | PhBL5 | G protein-coupled receptor 58
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from 3rd cytoplasmic domain of human TAAR2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (89%); Marmoset, Elephant, Panda, Bovine, Bat (84%).
Epitope
Cytoplasmic Domain
Specificity
Human TAAR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (1 - 3 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TAAR2 / GPR58
Validation
Skin, Malignant Melanoma
Skin, Malignant Melanoma
Brain, Glioblastoma
Brain, Glioblastoma
Anti-TAAR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TAAR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Pancreas, carcinoma
Pancreas, carcinoma
See More About...
LSBio Ratings
PathPlus™ TAAR2 / GPR58 Antibody (Cytoplasmic Domain) for IHC LS-A326 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/27/2024
Date Requested: 12/27/2024
