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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PathPlusTM LMNA / Lamin A+C Antibodies
Lamin A (LMNA, Lamin A/C) and Lamin B are the two types of lamins found in vertebrates. These proteins make up the matrix of the nuclear lamina that lines the inner nuclear membrane. Lamin A is functionally involved in gene expression, nuclear stability, the maintenance of neural circuit function and nervous system integrity, and chromatin structure. A number of diseases are caused by Lamin A mutations, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Wild-type Lamin A has also been found to be overexpressed in the hippocampus in the later stages of Alzheimer’s disease. In immunohistochemistry, Lamin A has high nuclear membrane positivity in all cell types throughout the body. References: Nat. Rev. Genet. 2006. 7 (12): 940–52, PMID: 17139325; Int J Mol Sci. 2019 Feb; 20(4): 878, PMID: 30781626; Cell Stress. 2018 Sep; 2(9): 219–224, PMID: 31223139

3 PathPlusTM Antibodies
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Antibodies (3)
Primary (3)
LMNA / Lamin A+C (3)
Human (3)
Mouse (2)
Rat (1)
Bovine (1)
Dog (1)
IHC (3)
IHC-Fr (1)
IHC-P (3)
WB (3)
Flo (2)
ICC (1)
IF (1)
IP (1)
rabbit (1)
mouse (2)
Product Group
PathPlus Neuro (3)
IgG (1)
IgG1 (1)
IgG3 (1)
monoclonal mc (2)
polyclonal pc (1)
133A2 (1)
JOL2 (1)
Unconjugated (3)
C-Terminus (1)
aa464-572 (1)
No (2)
Yes (1)
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Neuroscience
LMNA / Lamin A+C Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Neuroscience
LMNA / Lamin A+C Mouse anti-Human Monoclonal (aa464-572) (JOL2) Antibody
Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
0.05 ml/$485
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Neuroscience
LMNA / Lamin A+C Mouse anti-Human Monoclonal (133A2) Antibody
Mouse, Dog, Bovine, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$440
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