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order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Lamin A (LMNA, Lamin A/C) and Lamin B are the two types of lamins found in vertebrates. These proteins make up the matrix of the nuclear lamina that lines the inner nuclear membrane. Lamin A is functionally involved in gene expression, nuclear stability, the maintenance of neural circuit function and nervous system integrity, and chromatin structure. A number of diseases are caused by Lamin A mutations, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Wild-type Lamin A has also been found to be overexpressed in the hippocampus in the later stages of Alzheimer’s disease. In immunohistochemistry, Lamin A has high nuclear membrane positivity in all cell types throughout the body.
References: Nat. Rev. Genet. 2006. 7 (12): 940–52, PMID: 17139325; Int J Mol Sci. 2019 Feb; 20(4): 878, PMID: 30781626; Cell Stress. 2018 Sep; 2(9): 219–224, PMID: 31223139