Lamin A (LMNA, Lamin A/C) and Lamin B are the two types of lamins found in vertebrates. These proteins make up the matrix of the nuclear lamina that lines the inner nuclear membrane. Lamin A is functionally involved in gene expression, nuclear stability, the maintenance of neural circuit function and nervous system integrity, and chromatin structure. A number of diseases are caused by Lamin A mutations, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Wild-type Lamin A has also been found to be overexpressed in the hippocampus in the later stages of Alzheimer’s disease. In immunohistochemistry, Lamin A has high nuclear membrane positivity in all cell types throughout the body. References: Nat. Rev. Genet. 2006. 7 (12): 940–52, PMID: 17139325; Int J Mol Sci. 2019 Feb; 20(4): 878, PMID: 30781626; Cell Stress. 2018 Sep; 2(9): 219–224, PMID: 31223139