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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
FOXA1 (forkhead box A1, hepatocyte neuclear factor 3a, HNF3A) is a forkhead box domain transcription factor and nuclear steroid receptor involved in mediating sex hormone-dependent signaling in the differentiation and development of tissues such as the pancreas, liver, breast and prostate. Expression of FOXA1 has been associated with a good prognosis in hormone receptor positive breast cancer. It is a useful marker for luminal A type breast cancers, as it is often expressed in luminal subtypes independent of ER expression and it does not see expression in basal subtypes. In ER-negative tumors, a lack of FOXA1 expression is associated with worse prognosis, as loss of FOXA1 is associated with the consequential expression of metastases-prone, basal-specific proteins that it normally acts to directly repress. FOXA1 is expected to show nuclear expression in tissues such as prostate, breast, urothelium, the GI tract and respiratory epithelium.
References: EMBO J. 2011 30(19):3885; Bernardo, 2013; Algergaria, 2001; Gong, 2014; Expert Rev Mol Med 2009 5(11):e8; Breast Cancer Res 2009 11(3):R40; Mol Endocrinol 2010 24(8):1594; Ann Surg Oncol 2012 19(4):1145