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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
CD8A (CD8, Leu2, MAL, p32) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. CD8A mutations cause CD8 deficiency, described by frequent bacterial infections. In immunohistochemistry, CD8A has cytoplasmic positivity, and it is used to mark normal and malignant T cells, cytotoxic and suppressor T cells, cortical thymocytes, NK cells, and dendritic cells. In cancer, CD8A is used to classify lymphomas and identify CD8-positive melanomas. CD8A also distinguishes splenic hamartoma (positive) from hemangioma and littoral cell angioma (negative).
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; J Clin Invest 2001;108:117, PMID: 11435463; PLoS One 2010;5:e8437, PMID: 20052413;