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CD8A / CD8 Alpha
CD8a molecule
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | CD8a molecule |
| Synonyms: | CD8A, CD8a molecule, CD8a antigen, OKT8 T-cell antigen, Leu2 T-lymphocyte antigen, T8 T-cell antigen, T cell co-receptor, p32, CD8, Leu2, T-cell antigen Leu2 |
| Target Sequences: | NM_001768 NP_001759.3 P01732 |
Publications (12)
1
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. Thakral D, Dobbins J, Devine L, Kavathas PB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:7431-42.
[PubMed:18490743]
Related Antibodies: LS-C40806.
2
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH. Journal of translational medicine. 2009 7:89.
[PubMed:19849846]
[PMC:PMC2770477]
Related Antibodies: LS-C40806.
3
Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compared to. Awasthi S, Lubinski JM, Shaw CE, Barrett SM, Cai M, Wang F, Betts M, Kingsley S, Distefano DJ, Balliet JW, Flynn JA, Casimiro DR, Bryan JT, Friedman HM. Journal of virology. 2011 85:10472-86.
[PubMed:21813597]
[PMC:PMC3187515]
Related Antibodies: LS-C40805.
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(2)
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (CT-CD8a) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated
200 µg/$519
Cancer Pathology
Cancer
CD8A / CD8 Alpha Rabbit anti-Human Polyclonal (C-Terminus) (P17-V) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
125 µl/$515
CD8A / CD8 Alpha Mouse anti-Human Monoclonal (C8/468) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
CD8A / CD8 Alpha Rabbit anti-Human Polyclonal (aa150-180) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
CD8A / CD8 Alpha Rabbit anti-Human Polyclonal (aa150-180) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD8A / CD8 Alpha Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (YTS 169AG 101HL) Antibody
Mouse
Flo, IHC, IHC-Fr, IHC-Pfa
Unconjugated
250 µg/$382
CD8A / CD8 Alpha Mouse anti-Dog Monoclonal (Supernatant) (CA9.JD3) Antibody
Dog
Flo, IHC, IHC-Fr, IP
Unconjugated, Supernatant
2 ml/$509
CD8A / CD8 Alpha Mouse anti-Pig Monoclonal (76-2-11) Antibody
Pig
Flo, IHC, IHC-P, IP
Unconjugated
0.5 mg/$506
CD8A / CD8 Alpha Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, WB
Unconjugated
0.1 mg/$432
CD8A / CD8 Alpha Mouse anti-Pig Monoclonal (Biotin) (76-2-11) Antibody
Pig
Flo, IHC, IHC-P, IP
Biotin Conjugated
0.5 mg/$532
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (53-6.72) Antibody
Mouse
ELISA, Flo
Unconjugated
100 µg/$411
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (PE) (CT-CD8a) Antibody
Mouse
Flo
PE Conjugated
50 µg/$426; 300 µg/$1,141
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (FITC) (KT15) Antibody
Mouse
Flo
FITC Conjugated
0.1 mg/$432
CD8A / CD8 Alpha Mouse anti-Rabbit Monoclonal (PE) Antibody
Rabbit
Flo
PE Conjugated
100 µl/$901
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$715
CHO Cells
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.6 kDa
10 µg/$268; 50 µg/$349
CD8A / CD8 Alpha Mouse anti-Human Monoclonal (C-Terminus) (Azide-free, BSA-free) (C8/144B) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
50 µg/$460
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (G1/G1-4) Antibody
Mouse
Flo, IHC
Unconjugated
50 µg/$439; 500 µg/$688
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (FITC) (CT-CD8a) Antibody
Mouse
Flo, IHC, IHC-Fr
FITC Conjugated
100 µg/$412; 300 µg/$674
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (Biotin) (YTS169.4) Antibody
Mouse
Flo, IHC, IHC-Fr
Biotin Conjugated
100 µg/$312; 300 µg/$473
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (PE) (53-6.7) Antibody
Mouse
Flo, Func, ICC, IHC-Fr, IHC-P, IP
PE Conjugated
0.1 mg/$295
CD8A / CD8 Alpha Mouse anti-Human Monoclonal (HIT8a) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$226; 100 µg/$246
CD8A / CD8 Alpha Rat anti-Mouse Monoclonal (KT15) Antibody
Mouse
Flo, IF, IHC, IHC-Fr
Unconjugated
0.25 mg/$471
CD8A / CD8 Alpha Mouse anti-Human Monoclonal (Preservative Free) (38) Antibody
Mouse, Human
IHC-P
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
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of 383
product results
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