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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

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Customer Service: (800) 227-6666 / (650) 697-3600


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PathPlusTM CD274 / B7-H1 / PD-L1 Antibodies
PDL1 (CD274), or programmed cell death-ligand 1, is a transmembrane protein expressed in B and T cells that acts as an immune checkpoint regulator by suppressing the T-cell response. The primary receptor for PDL1 is PD1 (PDCD1), and binding of PDL1 to PD1 suppresses T cell migration, proliferation, and restricts tumor cell death. High levels of expression of PDL1 are associated with poor prognosis in certain carcinomas, and expression is also associated with EGFR mutations, the onset of which may directly lead to upregulation of PDL1. Current trials involving PDL1 inhibitors have shown impressive results in treating advanced stage cancers such as melanomas. This protein is expressed in the cytoplasm and membrane in normal immune cells, placental trophoblasts, and some cancers. References: Dong, H. et al. Nat Med. 2002 Aug;8(8):793-800. Epub 2002 Jun 24; Zhang, 2016; Chen 2015; Tang 2015; Nat Med 2002(8):793

3 PathPlusTM Antibodies
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Antibodies (3)
Primary (3)
CD274 / B7-H1 / PD-L1 (3)
Human (1)
IHC-P (3)
rabbit (3)
Product Group
PathPlus Cancer (3)
PathPlus Cancer Pathology (3)
IgG (1)
monoclonal mc (1)
polyclonal pc (2)
AHC0271 (1)
Unconjugated (3)
No (3)
CD274 / B7-H1 / PD-L1 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Monoclonal (AHC0271) Antibody
Human
IHC-P
Unconjugated
0.05 ml/$440
CD274 / B7-H1 / PD-L1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
Fast Shipping
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
CD274 / B7-H1 / PD-L1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
Fast Shipping
CD274 / B7-H1 / PD-L1 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
Viewing 1-3 of 3 product results