BCL10 (B-cell lymphoma/leukemia 10) is a cellular homolog of the equine herpesvirus-2 E-10 gene that functions to induce apoptosis by activating CASP9. When overexpressed, BCL10 induces JNK, p38, and NF-kB activation. BCL10 plays an important role in both activating and suppressing adaptive and innate immune signaling by connecting to various CARD scaffold proteins. BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas and participates in the pathogenesis of various malignancies. In immunohistochemistry of normal tissue, BLC10 has cytoplasmic positivity in most tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Front Immunol. 2018; 9: 1539, PMID: 30022982