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Catalog Number	Size	Price
LS-B746-50	50 µg (0.5 mg/ml)	$545

BCL10 / BCL-10 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

BCL10 / BCL-10 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

BCL10 / BCL-10 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

BCL10 / BCL-10 Antibody - Anti-BCL10 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

BCL10 / BCL-10 Antibody - Anti-BCL10 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

BCL10 / BCL-10 Antibody - Western blot of anti-Bcl-10 (NT) antibody at 1 ug/ml on Raji whole cell lysate in the absence (A) and presence (B) of blocking peptide.

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PathPlus™ Polyclonal Rabbit anti‑Human BCL10 / BCL‑10 Antibody (aa5‑19, IHC, WB) LS‑B746

Name: PathPlus™ BCL10 / BCL-10 Polyclonal Antibody Rabbit anti-Human | LSBio
Brand: Lifespan BioSciences
SKU: LS-B746-50
Price: 545.0000 USD
Availability: InStock
Rating: 5 (1 reviews)

Cancer

(5.0) Rating

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Note: This antibody replaces LS-C26611, LS-C4134

Antibody:

BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa5-19) Antibody

Application:

IHC, IHC-P, WB

Reactivity:

Human, Mouse, Rat

Format:

Unconjugated, Unmodified

$545

LS-B746-50

Toll Free North America

(800) 227-6666

For Research Use Only

Specifications Validation Publications Reviews Featured Products Request SDS/MSDS

Overview

Antibody:

BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa5-19) Antibody

Application:

IHC, IHC-P, WB

Reactivity:

Human, Mouse, Rat

Format:

Unconjugated, Unmodified

Specifications

Description

BCL10 (B-cell lymphoma/leukemia 10) is a cellular homolog of the equine herpesvirus-2 E-10 gene that functions to induce apoptosis by activating CASP9. When overexpressed, BCL10 induces JNK, p38, and NF-kB activation. BCL10 plays an important role in both activating and suppressing adaptive and innate immune signaling by connecting to various CARD scaffold proteins. BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas and participates in the pathogenesis of various malignancies. In immunohistochemistry of normal tissue, BLC10 has cytoplasmic positivity in most tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Front Immunol. 2018; 9: 1539, PMID: 30022982

Target

Human BCL10 / BCL-10

Synonyms

See All BCL10 / BCL-10 Antibodies

Host

Rabbit

Reactivity

Human, Mouse, Rat (tested or 100% immunogen sequence identity)

Clonality

Polyclonal

Conjugations

Unconjugated

Purification

Purified

Modifications

Unmodified

Immunogen

Synthetic peptide from human BCL10.

Epitope

aa5-19

Specificity

Amino acids 5-19 of human BLC10

Applications

IHC
IHC - Paraffin (10 - 20 µg/ml)
Western blot

Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.

Usage

Immunohistochemistry: LS-B746 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B746 was determined to be 10 ug/ml.

Presentation

PBS, 0.02% Sodium Azide

Storage

Store at 4°C or -20°C. Avoid freeze-thaw cycles.

Restrictions

For research use only. Intended for use by laboratory professionals.

Guarantee

This antibody carries the LSBio 100% Guarantee.

LSBio Guarantee

About BCL10 / BCL-10

Uniprot: O95999 NCBI: NM_003921 NP_003912.1

Validation

Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-BCL10 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Anti-BCL10 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

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PathPlus™ Validation Process