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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
DOG1 (TMEM16A, ANO1) is a transmembrane protein expressed in epithelial cells and smooth muscle cells throughout the gastrointestinal tract. It functions as a calcium-activated chloride channel and mediates intestinal motility. It is highly expressed in gastrointestinal stromal tumors (GISTs).
References: Pedemonte N, Galietta LJ (2014). "Structure and function of TMEM16 proteins (anoctamins)". Physiol. Rev. 94 (2): 419–59. doi:10.1152/physrev.00039.2011. PMID 24692353.