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ANO1 / DOG1 / TMEM16A

anoctamin 1, calcium activated chloride channel

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Gene Name: anoctamin 1, calcium activated chloride channel
Synonyms: ANO1, Oral cancer overexpressed 2, Transmembrane protein 16A, ORAOV2, Anoctamin-1, DOG1, TAOS2, TMEM16A
Target Sequences: NM_018043 NP_060513.5 Q5XXA6

Publications (2)

1
Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P. Cancer discovery. 2015 5:304-15. (IHC; Human) [Full Text Article] [PubMed:25572173] [PMC:PMC4355391]
2
Suppression of CaMKIIß Inhibits ANO1-Mediated Glioblastoma Progression. Kyoung Mi Sim, Young-Sun Lee, Hee Jin Kim, Chang-Hoon Cho, Gwan-Su Yi, Myung-Jin Park, Eun Mi Hwang, Jae-Yong Park. Cells. 2020 April;9: [Full Text Article] [PubMed:32357567] [PMC:PMC7290681]

☰ Filters
Antibodies (88)
Proteins (1)
Primary (88)
Recombinant (1)
ANO1 / DOG1 / TMEM16A (89)
Human (81)
Mouse (17)
Rat (9)
Bovine (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (2)
IHC (15)
IHC-Fr (2)
IHC-P (29)
WB (45)
ELISA (12)
ICC (2)
IF (7)
IHC-Fx (1)
Peptide-ELISA (2)
rabbit (48)
mouse (39)
rabbit-new zealand white (1)
Product Group
IHCPlus (1)
PathPlus Cancer (1)
PathPlus Cancer Pathology (1)
IgG (30)
IgG1 (14)
IgG1,k (11)
IgG2a (8)
IgG2b,k (6)
monoclonal mc (40)
polyclonal pc (44)
recombinant monoclonal rmc (4)
006 (1)
DG1/1484 (2)
DG1/1485 (2)
DG1/1486 (2)
DG1/2564R (2)
DG1/447 (3)
DG1/447 + DOG-1.1 (3)
DOG1.1 (1)
DOG-1.1 (3)
OTI1C6 (2)
OTI1C8 (2)
OTI1E6 (2)
OTI1H2 (2)
OTI2F4 (2)
OTI3A3 (2)
OTI5H2 (2)
OTI5H7 (2)
RBT-DOG1 (2)
SPM580 (2)
tDAN4 (3)
UMAB250 (2)
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Azide-free (10)
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aa1-333 (18)
aa20-239 (8)
aa453-482 (7)
aa904-986 (7)
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aa828-877 (4)
N-Terminus (2)
aa 2-101 (2)
890-970 aa, C-terminal (1)
aa921-970 (1)
aa927-943 (1)
No (89)
His-T7 (1)
Mouse (1)
E. coli (1)
ANO1 / DOG1 / TMEM16A Antibody - Western blot of fetal muscle lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa828-877) Antibody
Human
WB
Unconjugated
100 µl/$424
ANO1 / DOG1 / TMEM16A Antibody - Western blot analysis of extracts of various cell lines, using ANO1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
ANO1 / DOG1 / TMEM16A Antibody - Human Small Intestine, Myenteric Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ANO1 / DOG1 / TMEM16A Rabbit anti-Mouse Polyclonal (aa20-239) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ANO1 / DOG1 / TMEM16A Antibody - IHC of paraffin-embedded Human skin tissue using anti-ANO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI1C8) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Antibody - Immunohistochemical staining of paraffin-embedded Human skin tissue using anti-ANO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (Carrier-free) (OTI1C8) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$511
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
ANO1 / DOG1 / TMEM16A Antibody - IHC of DOG1 on FFPE GIST tissue Intended Use For In Vitro Diagnostic Use.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Recombinant Monoclonal (RBT-DOG1) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$369
ANO1 / DOG1 / TMEM16A Antibody - Formalin-fixed, paraffin-embedded human GIST stained with DOG1 antibody (DOG1.1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa904-986) (DOG-1.1) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
ANO1 / DOG1 / TMEM16A Antibody - Human Gastrointestinal Stromal Tumor: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Recombinant Monoclonal (aa 2-101) (DG1/2564R) Antibody
Human
IHC-Fx
Unconjugated
100 µg/$525
ANO1 / DOG1 / TMEM16A Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ANO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ANO1.
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI5H7) Antibody
Human
WB
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ANO1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ANO1.
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (Carrier-free) (OTI5H7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ANO1 / DOG1 / TMEM16A Antibody - WB of ANO1 / DOG1 / TMEM16A antibody. All lanes: Anti-ANO1 at 0.5ug/ml. Lane 1: Rat Liver Tissue Lysate at 40ug. Lane 2: Rat Skeletal Muscle Tissue Lysate at 40ug. Predicted bind size: 114KD. Observed bind size: 114KD.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa927-943) Antibody
Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
ANO1 / DOG1 / TMEM16A Antibody - ANO1 Antibody western blot of K562 cell line lysates (35 ug/lane). The ANO1 Antibody detected the ANO1 protein (arrow).
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa453-482) Antibody
Human
WB
Unconjugated
400 µl/$393
ANO1 / DOG1 / TMEM16A Antibody - IHC testing of human gastrointestinal stromal tumor (GIST) and DOG1 antibody (tDAN4).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (tDAN4) Antibody
Human
IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
ANO1 / DOG1 / TMEM16A Antibody - Anti-ANO1 rabbit monoclonal antibody at 1:500 dilution. Lane A: A549 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 114 kDa. Observed band size: 114 kDa.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Monoclonal (Preservative Free) (006) Antibody
Human
WB
Unconjugated, Preservative Free
100 µl/$412
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
Select
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, ICC, WB
Unconjugated
100 µl/$440; 200 µl/$468
ANO1 / DOG1 / TMEM16A Antibody - Western blot analysis of ANO1 using Jurkat whole lysates.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (890-970 aa, C-terminal) Antibody
Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ANO1 / DOG1 / TMEM16A Antibody - Immunohistochemistry image of paraffin-embedded human liver cancer at a dilution of 1:100
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Select
ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$331
ANO1 / DOG1 / TMEM16A Antibody - Peptide - + Immunofluorescence analysis of HeLa cells, using TM16A antibody.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
100 µg/$357
ANO1 / DOG1 / TMEM16A Antibody - IHC of paraffin-embedded Human adult heart tissue using anti-ANO1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa1-333) (OTI1H2) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
ANO1 / DOG1 / TMEM16A Antibody - Membranous staining of DOG1 in GIST
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ANO1 / DOG1 / TMEM16A Mouse anti-Human Monoclonal (aa904-986) (DOG1.1) Antibody
Human
IHC, IHC-P
Unconjugated
100 µg/$471
ANO1 / DOG1 / TMEM16A Antibody - Immunofluorescence analysis of HeLa cells, using TM16A Antibody. The picture on the right is blocked with the synthesized peptide.
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ANO1 / DOG1 / TMEM16A Rabbit anti-Human Polyclonal (aa921-970) Antibody
Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 89 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).