NTRK3 (TRK3, Tropomyosin receptor kinase C) is a neurotrophic tyrosine kinase receptor for neurotrophin NT-3. NTRK3 functions in the differentiation and survival of neurons. NTRK3 is also involved in regulating eating behavior and genetic variants in NTRK3 are associated with eating disorders. NTRK3 seems to be important for the development and plasticity of brain systems related to emotionality, and dosage imbalance of NTRK3 expression (and inter-individual variability in expression) may determine susceptibility to panic disorders and other related diseases. In congenital mesoblastic nephroma, NTRK3 – ETV6 gene fusions commonly occur in the cellular histological type of mesoblastic nephroma and are associated with greater relapse-free survival. In immunohistochemistry, NTRK3 has highest nuclear and cytoplasmic positivity in the cerebral cortex in the brain, and it is also found throughout the central nervous system and at lower levels throughout the body. References: Pediatr Blood Cancer. 2018 Apr;65(4), PMID: 29286563; Human Molecular Genetics. 2008. 17(9): 1234–1244, DOI: 10.1093/hmg/ddn013; Genes Brain Behav. 2007 Jun; 6 Suppl 1:2-23, PMID: 17543035