EGR2 (Early growth response protein 2, KROX20) is a transcription factor expressed in migrating neural crest cells and in neural crest-derived cells in the cranial ganglion. It is important for hindbrain development, maintenance of bone architecture, the lymphocyte immune response, regulation of HF cell differentiation, and Schwann cell myelination. EGR2 mutations are correlated with Charcot-Marie-Tooth disease, Dejerine-Stotas disease and congenital hypomyelinating neuropathy. Loss of EGR2 expression is believed to lead to male baldness. Furthermore, expression of this protein is associated with Ewing sarcoma. In immunohistochemistry, EGR2 has nuclear positivity in the brain, thyroid and epididymis, and it is also found at variable levels in a number of other tissues including the lung, liver, reproductive tissues, muscle, skin, gastrointestinal tract, and immune tissues. References: Nature. 337 (6206): 461–4, PMID: 2915691; Nucleic Acids Research. 21 (5): 1087–95, PMID: 8464695; Nature Genetics. 18 (4): 382–4, PMID: 9537424; J Biol Chem. 2013 Jul 12; 288(28): 20488–20498, PMID: 23720781; Genes Dev. 2017 Apr 15; 31(8): 744–756, PMID: 28465357