Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
| Catalog Number | Size | Price |
|---|---|---|
| LS-A7350-50 | 50 µg (1 mg/ml) | $460 |
1 of 6
2 of 6
3 of 6
4 of 6
5 of 6
6 of 6
PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350
PathPlus™ Polyclonal Rabbit anti‑Human CDK12 / CRKRS Antibody (Internal, IHC) LS‑A7350
Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Overview
Antibody:
CDK12 / CRKRS Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
Cyclin-dependent kinase 12 (CDK12) phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. CDK12 regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. It preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. CDK12 is required for RNA splicing, possibly by phosphorylating SRSF1/SF2 and is involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CDK12 / CRKRS
Synonyms
CDK12 | CDC2-related protein kinase 7 | CRK7 | Cyclin-dependent kinase 12 | HCDK12 | KIAA0904 | CRKR | CRKRS | Pksc
Host
Rabbit
Reactivity
Human, Monkey, Dog
(tested or 100% immunogen sequence identity)
Predicted
Rat, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from internal region of human CDK12 / CRKRS. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Dog (100%); Elephant, Bovine, Rabbit (95%); Rat, Bat (90%); Mouse, Hamster, Horse (85%).
Epitope
Internal
Specificity
Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except AKAP12 (55%).
Applications
- IHC
- IHC - Paraffin (6 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CDK12 / CRKRS
Validation
Breast, Carcinoma
Breast, Carcinoma
Prostate, cancer
Prostate, cancer
Brain, Substantia Nigra, nonpigmented neurons
Brain, Substantia Nigra, nonpigmented neurons
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human breast carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CDK12 / CRKRS antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ CDK12 / CRKRS Antibody (Internal) for IHC LS-A7350 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
Western blot, Immunoprecipitation
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/24/2024
Date Requested: 12/24/2024
