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BMP4

bone morphogenetic protein 4

BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Gene Name: bone morphogenetic protein 4
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: BMP4, BMP-2B, BMP-4, BMP2B, BMP2B1, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, Zyme
Target Sequences: NM_001202 NP_001193.2 P12644

Publications (3)

1
Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM. Science immunology. 2018 January;3:pii: eaal2736. [Full Text Article] [PubMed:29330161] [PMC:PMC5795617]
2
Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats. Xu Yang, Na Niu, Chen Liang, Ming-Ming Wu, Liang-Liang Tang, Qiu-Shi Wang, Jie Lou, Bin-Lin Song, Wei-Wan Zheng, He-Ping Ma, Zhi-Ren Zhang. Oxidative medicine and cellular longevity. 2020 November;2020:3921897. [Full Text Article] [PubMed:33194000] [PMC:PMC7641672]
3
Potential Role of Circulating Endoglin in Hypertension via the Upregulated Expression of BMP4. Eunate Gallardo-Vara, Luis Gamella-Pozuelo, Lucía Perez-Roque, José L Bartha, Irene Garcia-Palmero, J Ignacio Casal, José M López-Novoa, Miguel Pericacho, Carmelo Bernabeu. Cells. 2020 Apr;9:988. [Full Text Article] [PubMed:32316263] [PMC:PMC7226995]

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BMP4 Mouse anti-Mouse Monoclonal (3H2.3) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
Unconjugated
100 µg/$826
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BMP4 Mouse anti-Mouse Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, ICC, WB
APC Conjugated
100 µl/$1,049
BMP4 Antibody - Immunohistochemistry of paraffin-embedded Human brain using BMP4 Polyclonal Antibody at dilution of 1:25.
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BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$441
BMP4 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$851
BMP4 Protein - Recombinant Bone Morphogenetic Protein 4 By SDS-PAGE
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E. coli
His
17.8 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
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E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
2 µg/$268; 10 µg/$349
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
BMP4 Antibody - Immunohistochemistry of paraffin-embedded human prostate cancer tissue.
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BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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BMP4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
BMP4 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Rat
13.72 - 10000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$911
BMP4 Antibody - Immunohistochemical staining of paraffin-embedded human stomach carcinoma using BMP4 clone UMAB42, mouse monoclonal antibody at 1:100 dilution of 1mg/mL using Polink2 Broad HRP DAB for detection.requires heat-induced epitope retrieval with Accel pH8.7 at 110C for 3 min using pressure chamber/cooker. The image shows strong membranous and cytoplasmic staining.
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BMP4 Mouse anti-Human Monoclonal (aa293-408) (Carrier-free) (UMAB42) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
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BMP4 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
BMP4 Protein - Recombinant Bone Morphogenetic Protein 4 By SDS-PAGE
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E. coli
His
22.2 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
BMP4 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BMP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC-P, WB
Unconjugated
60 µl/$460
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BMP4 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
BMP4 Antibody - Immunohistochemical staining of paraffin-embedded human stomach carcinoma using BMP4 clone UMAB42, mouse monoclonal antibody at 1:100 dilution of 1mg/mL using Polink2 Broad HRP DAB for detection.requires heat-induced epitope retrieval with Accel pH8.7 at 110C for 3 min using pressure chamber/cooker. The image shows strong membranous and cytoplasmic staining.
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BMP4 Mouse anti-Human Monoclonal (aa293-408) (UMAB42) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
BMP4 Antibody - Western blot of recombinant BMP4 / BMP-4.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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BMP4 Rabbit anti-Cow Polyclonal (aa219-392) Antibody
Mouse, Bovine, Rat, Cow, Human
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
BMP4 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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BMP4 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
BMP4 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
BMP4 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
BMP4 ELISA Kit
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Sandwich
96-Well Microplate
Human
15 - 6000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
BMP4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BMP4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
BMP4 Protein - Recombinant Bone Morphogenetic Protein 4 By SDS-PAGE
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E. coli
His
14.4 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Viewing 1-25 of 202 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).