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| Catalog Number | Size | Price |
|---|---|---|
| LS-B13223-100 | 100 µl (1 mg/ml) | $485 |
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PathPlus™ Monoclonal Mouse anti‑Human ARG1 / Arginase 1 Antibody (clone 4E6, IHC, WB) LS‑B13223
PathPlus™ Monoclonal Mouse anti‑Human ARG1 / Arginase 1 Antibody (clone 4E6, IHC, WB) LS‑B13223
Note: This antibody replaces LS-C337257
Antibody:
ARG1 / Arginase 1 Mouse anti-Human Monoclonal (4E6) Antibody
Application:
IHC, IHC-P, WB, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
ARG1 / Arginase 1 Mouse anti-Human Monoclonal (4E6) Antibody
Application:
IHC, IHC-P, WB, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Arginase 1 (ARG1) is a cytosolic enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. Mutations in the ARG1 gene result in impaired ureagenesis. ARG1 is expressed mainly in liver hepatocytes and to a lesser extent in subsets of bone marrow cells. It is also expressed in hepatocellular carcinoma. ARG1 antibodies are used to identify benign and malignant hepatocytes with high specificity and sensitivity and to differentiate hepatocellular carcinoma from metastatic carcinoma. Staining can also be used to identify subsets of cholangiocarcinomas.
References: Am J Surg Pathol. 2010;34(8):1147-1154. doi: 10.1097/PAS.0b013e3181e5dffa; Adv Anat Pathol. 2014;21(4):285-290. doi: 10.1097/PAP.0000000000000022; Diagn Pathol. 2012;7:149. doi: 10.1186/1746-1596-7-149; Blood. 2005;105(6):2549-2556. doi: 10.1182/blood-2004-07-2521; Oncol Lett. 2011;2(6):1041-1046. doi: 10.3892/ol.2011.405; J Mol Med (Berl). 2015;93(12):1287-1296. doi: 10.1007/s00109-015-1354-3.
Target
Human ARG1 / Arginase 1
Synonyms
ARG1 | Arginase, liver | Arginase 1 | Liver-type arginase | Liver arginase | Arginase-1 | Type I arginase
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
4E6
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Full length human recombinant protein of human ARG1 (NP_000036) produced in HEK293T cell.
Specificity
Human ARG1 / Arginase 1
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- Western blot (1:1000 - 1:2000)
- Flow Cytometry (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol, 1% BSA
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ARG1 / Arginase 1
Validation
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ ARG1 / Arginase 1 Antibody (clone 4E6) for IHC, WB/Western, Flow LS-B13223 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
