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| Catalog Number | Size | Price |
|---|---|---|
| LS-B3020-50 | 50 µg (0.5 mg/ml) | $485 |
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2 of 2
PathPlus™ Polyclonal Goat anti‑Human ALK2 / ACVR1 Antibody (aa147‑161, IHC, WB) LS‑B3020
PathPlus™ Polyclonal Goat anti‑Human ALK2 / ACVR1 Antibody (aa147‑161, IHC, WB) LS‑B3020
Note: This antibody replaces LS-C54445
Antibody:
ALK2 / ACVR1 Goat anti-Human Polyclonal (aa147-161) Antibody
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
ALK2 / ACVR1 Goat anti-Human Polyclonal (aa147-161) Antibody
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
ACVR1 (ALK-2, Activin A receptor, type I) is transmembrane receptor of the transforming growth factor-beta (TGF-beta) superfamily that is involved in growth and differentiation. It is important for neurogenesis as well as the development and repair of the skeletal system via its involvement in the BMP (bone morphogenic) pathway. Mutations in this gene are associated with fibrodysplasia ossificans progressive as well as diffuse intrinsic pontine glioma (DIPG). In immunohistochemistry, ACVR1 has cytoplasmic positivity throughout the body.
References: Pediatr Endocrinol Rev. 2013 Jun;10 Suppl 2:437-48, PMID: 23858627; Nat Genet. 2006 May;38(5):525-7, PMID: 16642017; Nat Genet. 2014 May;46(5):457-461, PMID: 24705252; Journal of Neuroscience. 2013. 33 (16): 6766-6775, DOI: 10.1523/JNEUROSCI.0128-13.2013;
Target
Human ALK2 / ACVR1
Synonyms
ACVR1 | Activin A receptor type I | Activin A receptor, type I | ACTR-I | ActRIA | ACVR1A | ALK2 | Activin receptor-like kinase 2 | Activin receptor type-1 | ACTRI | ACVRLK2 | ALK-2 | Activin receptor type I | Actr1 | FOP | Hydroxyalkyl-protein kinase | SKR1 | TSRI | TSR-I | Tsk7L
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-RKFKRRNQERLNPRD, from the internal region of the protein sequence according to NP_001096.1.
Epitope
aa147-161
Specificity
Human ACVR1 / ALK2.
Applications
- IHC
- IHC - Paraffin (4 µg/ml)
- Western blot (0.3 - 1 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B3020 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3020 was determined to be 4 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ALK2 / ACVR1
Validation
Anti-ACVR1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Anti-ACVR1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
See More About...
LSBio Ratings
PathPlus™ ALK2 / ACVR1 Antibody (aa147-161) for IHC, WB/Western LS-B3020 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, Western blot, Flow Cytometry, ELISA
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Xenopus
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Mouse, Human
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
