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| Catalog Number | Size | Price |
|---|---|---|
| LS-B11761-200 | 200 µl | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human ALK2 / ACVR1 Antibody (aa138‑170, IHC, WB) LS‑B11761
PathPlus™ Polyclonal Rabbit anti‑Human ALK2 / ACVR1 Antibody (aa138‑170, IHC, WB) LS‑B11761
Note: This antibody replaces LS-C98078
Antibody:
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa138-170) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
ALK2 / ACVR1 Rabbit anti-Human Polyclonal (aa138-170) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
ACVR1 (ALK-2, Activin A receptor, type I) is transmembrane receptor of the transforming growth factor-beta (TGF-beta) superfamily that is involved in growth and differentiation. It is important for neurogenesis as well as the development and repair of the skeletal system via its involvement in the BMP (bone morphogenic) pathway. Mutations in this gene are associated with fibrodysplasia ossificans progressive as well as diffuse intrinsic pontine glioma (DIPG). In immunohistochemistry, ACVR1 has cytoplasmic positivity throughout the body.
References: Pediatr Endocrinol Rev. 2013 Jun;10 Suppl 2:437-48, PMID: 23858627; Nat Genet. 2006 May;38(5):525-7, PMID: 16642017; Nat Genet. 2014 May;46(5):457-461, PMID: 24705252; Journal of Neuroscience. 2013. 33 (16): 6766-6775, DOI: 10.1523/JNEUROSCI.0128-13.2013;
Target
Human ALK2 / ACVR1
Synonyms
ACVR1 | Activin A receptor type I | Activin A receptor, type I | ACTR-I | ActRIA | ACVR1A | ALK2 | Activin receptor-like kinase 2 | Activin receptor type-1 | ACTRI | ACVRLK2 | ALK-2 | Activin receptor type I | Actr1 | FOP | Hydroxyalkyl-protein kinase | SKR1 | TSRI | TSR-I | Tsk7L
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Cow (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Epitope
aa138-170
Specificity
This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-170 amino acids from the Central region of human Activin Receptor Type IA (ACVR1).
Applications
- IHC
- IHC - Paraffin (1:50 - 1:100)
- Western blot (1:1000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.09% Sodium Azide
Storage
Maintain refrigerated at 2°C to 8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ALK2 / ACVR1
Validation
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ ALK2 / ACVR1 Antibody (aa138-170) for IHC, WB/Western LS-B11761 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M Carcaboso, Rheal A Towner. Journal of translational medicine. 2020 November;18:424.
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, Western blot, Flow Cytometry, ELISA
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Xenopus
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
