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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16117-100 | 100 µl (1 mg/ml) | $460 |
PathPlus™ Monoclonal Mouse anti‑Human ACTH Antibody (IHC) LS‑B16117
PathPlus™ Monoclonal Mouse anti‑Human ACTH Antibody (IHC) LS‑B16117
Note: This antibody replaces LS-C744444
Antibody:
ACTH Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
ACTH Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Adrenocorticotropic hormone (ACTH) is a polypeptide tropic hormone. Part of the hypothalamic-pituitary-adrenal axis, it stimulates the secretion of steroid hormones from the adrenal cortex. It also exerts effects on osteoblasts. ACTH is expressed and secreted by corticotropes in the anterior pituitary gland and is also expressed at lower levels in the brain, adrenal medulla, skin, and placenta and at higher levels in ACTH-secreting tumors. Staining is used to identify ACTH-secreting tumors such as pituitary adenomas and nonpituitary tumors such as pancreatic neuroendocrine neoplasms and pancreatic acinar cell carcinomas and pancreatoblastomas.
References: J Mol Endocrinol. 2016;56(4):T135-T156. doi: 10.1530/JME-15-0257;Microsc Res Tech. 2003;61(3):308-314. PMID: 12768546;J Neuroendocrinol. 2008;20(6):692-699. doi: 10.1111/j.1365-2826.2008.01709.x;Am J Surg Pathol. 2015;39(3):374-382. doi: 10.1097/PAS.0000000000000340;Ann N Y Acad Sci. 2009;1163:93-100. doi: 10.1111/j.1749-6632.2009.04434.x.
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Synthetic ACTH-Adrenocorticotropin (ACTH)
Applications
- IHC (1:200 - 1:400)
- IHC - Paraffin (1:50)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Use Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH 8.0 Recommended IHC controls tissues are Pituitary. Resulting localization is Cytoplasmic
Presentation
0.5% BSA, 0.1% Kathon, Tris-Buffered Saline, DI H2O and 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
Validation
Human Anterior Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Anterior Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ ACTH Antibody for IHC LS-B16117 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Rat
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Rat
Applications:
IHC, IHC - Paraffin, ICC, ELISA
Species:
Human, Mouse, Rat, Pig
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/25/2024
Date Requested: 12/25/2024
