Target
Human ZKSCAN3 / ZNF306
Synonyms
ZKSCAN3 | DJ874C20.1 | DJ874C20.1. | KIAA0426 | Zfp-47 | ZFP306 | Zinc finger protein 309 | ZNF306 | ZNF309 | ZSCAN13 | ZSCAN35 | ZF47 | Zinc finger protein 306 | Zinc finger protein zfp47 | Zfp47 | Zinc finger protein 47 homolog
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant Human Zinc finger protein with KRAB and SCAN domains 3 protein (8-275AA)
Specificity
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.