Human TYRP1 / gp75

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Recombinant Monoclonal

TYRP1/2340R

Unconjugated

Protein A/G purified

Azide-free, Carrier-free. Also available Unmodified.

Recombinant fragment of human TYRP1 protein (around aa 257-377). Antigen Molecular Weight: 75 kDa

aa 257-377

It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

• IHC - Paraffin (1 - 2 µg/ml)
• ELISA (2 - 4 µg/ml)

ELISA (Use Ab at 2-4 ug/ml for coating) - Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.

10 mM PBS

Store at -20°C to -80°C for up to 2 years.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P17643 NCBI: NM_000550 NP_000541.1