Mouse TNFRSF18 / GITR

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG2b,l Monoclonal

DTA-1

Unconjugated

Protein G purified

Unmodified. Also available Azide-free, BSA-free.

Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody.

Mouse TNFRSF18 / GITR

• Immunofluorescence (0.5 - 1 µg/ml)
• Flow Cytometry (0.5 - 1 µg/10E6 cells)

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. Optimal dilution of the GITR antibody should be determined by the researcher.

1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9Y5U5 NCBI: NM_004195 NP_004186.1