Target
Human NR5A2 / LRH-1
Synonyms
NR5A2 | B1F | B1F2 | B1-binding factor | CPF | CYP7A promoter-binding factor | FTZ-F1beta | FTF | Liver receptor homolog 1 | LRH1 | LRH-1 | HB1F | HB1F-2 | Nuclear receptor phr-1 | FTZ-F1 | Liver receptor homolog-1 | Nuclear receptor NR5A2 | Receptor phr
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Nuclear receptor subfamily 5 group A member 2 protein (182-291AA)
Specificity
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.