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NR5A2 / LRH-1
nuclear receptor subfamily 5, group A, member 2
Alpha1-fetoprotein transcription factor (Ftf), a NR5 fushi tarazu-like receptor, also is known as 'human B1-binding factor' (HB1F), 'CYP7A promoter-binding factor' (CPF), and 'liver receptor homolog 1' (LRH1). Ftf has been shown to affect the transcription of hepatic genes including alpha fetoprotein encoding gene (AFP), viral hepatitis B enhancer II, and 7-alpha-hydroxylase encoding gene (CYP7A1). Ftf has also been shown to affect hepatic cholesterol metabolism and bile acid synthesis. Ftf has been shown to regulate aromatase activities in adipose tissue, and alterations in Ftf expression and/or activity in adipose tissue could have considerable effects on local estrogen production and breast cancer development. LRH has been shown to expressly strongly in gonadal tissues, and may play an important role in the regulation of gonadal function. Three isoforms of Ftf have been identified: wild type (495 aa), CPF variant 1 (contains a 46-aa insertion in the A/B domain), and CPF variant 2 (contains a 172-aa deletion within the D/E domain).
| Gene Name: | nuclear receptor subfamily 5, group A, member 2 |
| Family/Subfamily: | NHR , NR5 Fushi tarazu-like |
| Synonyms: | NR5A2, B1F, B1F2, B1-binding factor, CPF, CYP7A promoter-binding factor, FTZ-F1beta, FTF, Liver receptor homolog 1, LRH1, LRH-1, HB1F, HB1F-2, Nuclear receptor phr-1, FTZ-F1, Liver receptor homolog-1, Nuclear receptor NR5A2, Receptor phr |
| Target Sequences: | NM_003822 NP_003813.1 O00482 |
Publications (1)
1
Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:16927-31. (IHC-P; Human)
[Full Text Article]
[PubMed:21949357]
[PMC:PMC3193228]
Related Antibodies: LS-A2447.
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NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Cancer
Fast Shipping
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (Internal) Antibody
Xenopus, Chicken, Zebrafish, Horse, Rat, Hamster, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
NR5A2 / LRH-1 Mouse anti-Human Monoclonal (aa1-303) (OTI3H8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NR5A2 / LRH-1 Mouse anti-Human Monoclonal (aa1-303) (Carrier-free) (OTI3H8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa1-67) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa140-190) Antibody
Chicken, Bovine, Mouse, Dog, Guinea pig, Horse, Hamster-Chinese, Human, Primate
IHC, IHC-P, WB
Unconjugated
0.1 mg/$386
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal (aa314-342) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NR5A2 / LRH-1 Rabbit anti-Mouse Polyclonal (aa200-233) Antibody
Mouse, Rat
Peptide-ELISA, WB
Unconjugated
400 µl/$393
NR5A2 / LRH-1 Goat anti-Human Polyclonal Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR5A2 / LRH-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NR5A2 / LRH-1 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
WB
Unconjugated
100 µl/$424
NR5A2 / LRH-1 Goat anti-Human Polyclonal (aa233-246) Antibody
Chicken, Sheep, Bovine, Rat, Pig, Horse, Bat, Mouse, Guinea pig, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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