Human ITGB4 / Integrin Beta 4

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2a,k Monoclonal

UM-A9

Unconjugated

Protein G purified

Unmodified. Also available Azide-free, BSA-free.

The human squamous cell carcinoma line (UM-SCC1).

Human ITGB4 / Integrin Beta 4

• Immunofluorescence (0.5 - 1 µg/ml)
• Flow Cytometry (0.5 - 1 µg/10E6 cells)
• Blocking

This antibody recognizes a protein of 205kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ELISA: Order BSA-free format for coating.

1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P16144 NCBI: NM_000213 NP_000204.3