Human ITGA6/Integrin Alpha 6/CD49f

Rat

Human (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

NKI-GoH3

Unconjugated. Also available conjugated with RPE.

Protein G purified

Unmodified

BALB/c mouse mammary tumor cells

Recognizes the CD49f-antigen, (VLA-6 alpha-chain). CD49f can form distinct complexes with either the CD29-antigen (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukemia cells (alpha-6 beta-1). In immunohistology this Reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor. This clone has been reported to inhibit platelet adhesion to laminin.

• IHC - Frozen
• Immunofluorescence
• Immunoprecipitation
• Flow Cytometry

Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 platelets in 100 ul. Method sheets are available on request.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P23229 NCBI: NM_000210 NP_000201.2